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Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925804/ https://www.ncbi.nlm.nih.gov/pubmed/31885947 http://dx.doi.org/10.1155/2019/6414921 |
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author | Pivovarova, Aleksandra I. Patrick, Stephanie Reddy, Punuru J. |
author_facet | Pivovarova, Aleksandra I. Patrick, Stephanie Reddy, Punuru J. |
author_sort | Pivovarova, Aleksandra I. |
collection | PubMed |
description | Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing's Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes. |
format | Online Article Text |
id | pubmed-6925804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-69258042019-12-29 Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome Pivovarova, Aleksandra I. Patrick, Stephanie Reddy, Punuru J. Case Rep Endocrinol Case Report Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing's Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes. Hindawi 2019-12-08 /pmc/articles/PMC6925804/ /pubmed/31885947 http://dx.doi.org/10.1155/2019/6414921 Text en Copyright © 2019 Aleksandra I. Pivovarova et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Pivovarova, Aleksandra I. Patrick, Stephanie Reddy, Punuru J. Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
title | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
title_full | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
title_fullStr | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
title_full_unstemmed | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
title_short | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
title_sort | sporadic medullary thyroid carcinoma with paraneoplastic cushing syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925804/ https://www.ncbi.nlm.nih.gov/pubmed/31885947 http://dx.doi.org/10.1155/2019/6414921 |
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