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Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome

Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as...

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Autores principales: Pivovarova, Aleksandra I., Patrick, Stephanie, Reddy, Punuru J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925804/
https://www.ncbi.nlm.nih.gov/pubmed/31885947
http://dx.doi.org/10.1155/2019/6414921
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author Pivovarova, Aleksandra I.
Patrick, Stephanie
Reddy, Punuru J.
author_facet Pivovarova, Aleksandra I.
Patrick, Stephanie
Reddy, Punuru J.
author_sort Pivovarova, Aleksandra I.
collection PubMed
description Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing's Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes.
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spelling pubmed-69258042019-12-29 Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome Pivovarova, Aleksandra I. Patrick, Stephanie Reddy, Punuru J. Case Rep Endocrinol Case Report Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing's Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes. Hindawi 2019-12-08 /pmc/articles/PMC6925804/ /pubmed/31885947 http://dx.doi.org/10.1155/2019/6414921 Text en Copyright © 2019 Aleksandra I. Pivovarova et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Pivovarova, Aleksandra I.
Patrick, Stephanie
Reddy, Punuru J.
Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
title Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
title_full Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
title_fullStr Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
title_full_unstemmed Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
title_short Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
title_sort sporadic medullary thyroid carcinoma with paraneoplastic cushing syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925804/
https://www.ncbi.nlm.nih.gov/pubmed/31885947
http://dx.doi.org/10.1155/2019/6414921
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