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An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy

PURPOSE: We developed a mathematic empirical model for describing the small field penumbra in order to analyze the potential dose perturbation caused by overlapping field to avoid the dose calculation errors in linear accelerator-based radiosurgery. MATERIALS AND METHODS: A ball phantom was fabricat...

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Autores principales: Tang, Shi-Qiang, Jen, Yee-Min, Wu, Jia-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925912/
https://www.ncbi.nlm.nih.gov/pubmed/31886248
http://dx.doi.org/10.1155/2019/7584743
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author Tang, Shi-Qiang
Jen, Yee-Min
Wu, Jia-Ming
author_facet Tang, Shi-Qiang
Jen, Yee-Min
Wu, Jia-Ming
author_sort Tang, Shi-Qiang
collection PubMed
description PURPOSE: We developed a mathematic empirical model for describing the small field penumbra in order to analyze the potential dose perturbation caused by overlapping field to avoid the dose calculation errors in linear accelerator-based radiosurgery. MATERIALS AND METHODS: A ball phantom was fabricated for measuring penumbra at 4 different gantry angles in the coplanar plane. A least square root estimation (LSRE) Model was created to fit the measured penumbra dose profile and to predict the penumbra dose profile at any gantry angles. The Sum of Squared Errors (SSE) was used for finding the parameters n and t for the best fitting of the LSRE model. Geometric and mathematical methods were used to derive the model parameters. RESULTS: The results showed that the larger the gantry angle of the field, the more the expansion of the penumbra dose profile. The least square root estimation model for describing small field penumbra is as follows: [Formula: see text] where Penumbra(D(š)) denotes the dose profile D(š) at the penumbra region, T is the penumbra height (usually in scalar 100), n is the parameter for curvature, š = x − W (d)/2 (x and š are the values in cm on x-axis), and t is the radiation transmission of the collimator. Geometric analysis establishes the correlation between the penetration depth of the exposure and its effect on the penumbra region in ball phantom. The penumbra caused by an exposure at any arbitrary angles can be geometrically derived by using a one-variable quadratic equation. CONCLUSION: The dose distribution in penumbra region of small field can be created by the LSRE model and the potential overdosage or underdosage owing to overlapping field perturbation can be estimated.
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spelling pubmed-69259122019-12-29 An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy Tang, Shi-Qiang Jen, Yee-Min Wu, Jia-Ming Biomed Res Int Research Article PURPOSE: We developed a mathematic empirical model for describing the small field penumbra in order to analyze the potential dose perturbation caused by overlapping field to avoid the dose calculation errors in linear accelerator-based radiosurgery. MATERIALS AND METHODS: A ball phantom was fabricated for measuring penumbra at 4 different gantry angles in the coplanar plane. A least square root estimation (LSRE) Model was created to fit the measured penumbra dose profile and to predict the penumbra dose profile at any gantry angles. The Sum of Squared Errors (SSE) was used for finding the parameters n and t for the best fitting of the LSRE model. Geometric and mathematical methods were used to derive the model parameters. RESULTS: The results showed that the larger the gantry angle of the field, the more the expansion of the penumbra dose profile. The least square root estimation model for describing small field penumbra is as follows: [Formula: see text] where Penumbra(D(š)) denotes the dose profile D(š) at the penumbra region, T is the penumbra height (usually in scalar 100), n is the parameter for curvature, š = x − W (d)/2 (x and š are the values in cm on x-axis), and t is the radiation transmission of the collimator. Geometric analysis establishes the correlation between the penetration depth of the exposure and its effect on the penumbra region in ball phantom. The penumbra caused by an exposure at any arbitrary angles can be geometrically derived by using a one-variable quadratic equation. CONCLUSION: The dose distribution in penumbra region of small field can be created by the LSRE model and the potential overdosage or underdosage owing to overlapping field perturbation can be estimated. Hindawi 2019-12-07 /pmc/articles/PMC6925912/ /pubmed/31886248 http://dx.doi.org/10.1155/2019/7584743 Text en Copyright © 2019 Shi-Qiang Tang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tang, Shi-Qiang
Jen, Yee-Min
Wu, Jia-Ming
An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy
title An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy
title_full An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy
title_fullStr An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy
title_full_unstemmed An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy
title_short An Empirical Model for Describing the Small Field Penumbra in Radiation Therapy
title_sort empirical model for describing the small field penumbra in radiation therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925912/
https://www.ncbi.nlm.nih.gov/pubmed/31886248
http://dx.doi.org/10.1155/2019/7584743
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