Cargando…

Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway

Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which results in cardiac hypertrophy and subsequent heart failure. Chronic inflammation in the diabetic heart results in loss of cardiomyocytes and subsequentially cardiac dysfunction. Accumulated evidence impl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Hong, Bu, Rui, Yang, Qinghui, Jia, Jing, Li, Tao, Wang, Qiuping, Chen, Yanjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925927/ https://www.ncbi.nlm.nih.gov/pubmed/31886288 http://dx.doi.org/10.1155/2019/8905917

Ejemplares similares

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway
por: Jia, Yifan, et al.
Publicado: (2020)

Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway
por: An, Xin, et al.
Publicado: (2020)

Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs
por: Liu, Fangfang, et al.
Publicado: (2022)

Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway
por: Zhang, Jing, et al.
Publicado: (2020)

MiR-599 Protects Cardiomyocytes against Oxidative Stress-Induced Pyroptosis
por: Fan, Xiaoying, et al.
Publicado: (2021)

Metformin Protects against Spinal Cord Injury and Cell Pyroptosis via AMPK/NLRP3 Inflammasome Pathway
por: Yuan, Yajiang, et al.
Publicado: (2022)

miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis
por: Chen, Zhi-Qing, et al.
Publicado: (2021)

Galectin-3 induces vascular smooth muscle cells calcification via AMPK/TXNIP pathway
por: Tian, Lei, et al.
Publicado: (2022)

KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway
por: Lin, Guofu, et al.
Publicado: (2022)

Albumin-binding tag derived Exendin-4 analogue for treating hyperglycemia and diabetic complications
por: Xu, Shujuan, et al.
Publicado: (2022)

Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation
por: Luo, Tianyu, et al.
Publicado: (2022)

Considering the protective effect of exendin-4 against oxidative stress in spiral ganglion neurons
por: Wu, Hongxia, et al.
Publicado: (2023)

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats
por: Yu, Jing, et al.
Publicado: (2020)

PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway
por: Li, Zeyu, et al.
Publicado: (2022)

Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways
por: Lee, Shih-Yi, et al.
Publicado: (2015)

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway
por: Zheng, Tao, et al.
Publicado: (2018)

Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo
por: Jiao, Zhenyu, et al.
Publicado: (2021)

Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis
por: Shao, Xiaoqi, et al.
Publicado: (2022)

Exendin-4 inhibits high-altitude cerebral edema by protecting against neurobiological dysfunction
por: Sun, Zhong-Lei, et al.
Publicado: (2018)

Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue
por: Koenen, Tim B., et al.
Publicado: (2011)

Co-Crystal of Rosiglitazone With Berberine Ameliorates Hyperglycemia and Insulin Resistance Through the PI3K/AKT/TXNIP Pathway In Vivo and In Vitro
por: He, Qichen, et al.
Publicado: (2022)

An α(2)-adrenoceptor agonist: Dexmedetomidine induces protective cardiomyocyte hypertrophy through mitochondrial-AMPK pathway
por: Weng, Xiaojian, et al.
Publicado: (2020)

Signaling Pathway of Taurine-Induced Upregulation of TXNIP
por: Satsu, Hideo, et al.
Publicado: (2022)

MiR-17-5p Inhibits TXNIP/NLRP3 Inflammasome Pathway and Suppresses Pancreatic β-Cell Pyroptosis in Diabetic Mice
por: Liu, Sijun, et al.
Publicado: (2021)

The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway
por: Wu, Wei-Yin, et al.
Publicado: (2018)

Exendin-4 Protected against Cognitive Dysfunction in Hyperglycemic Mice Receiving an Intrahippocampal Lipopolysaccharide Injection
por: Huang, Hei-Jen, et al.
Publicado: (2012)

Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress
por: Yue, Rongchuan, et al.
Publicado: (2022)

Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation
por: Huang, Pian-Pian, et al.
Publicado: (2020)

The GLP-1R Agonist Exendin-4 Attenuates Hyperglycemia-Induced Chemoresistance in Human Endometrial Cancer Cells Through ROS-Mediated Mitochondrial Pathway
por: Zhang, Yu, et al.
Publicado: (2021)

Paeoniflorin Protects H9c2 Cardiomyocytes against Hypoxia/Reoxygenation Induced Injury via Regulating the AMPK/Nrf2 Signaling Pathway
por: Yu, Wen, et al.
Publicado: (2022)

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression
por: Heo, Mi Jeong, et al.
Publicado: (2019)

Retracted: Paeoniflorin Protects H9c2 Cardiomyocytes against Hypoxia/Reoxygenation Induced Injury via Regulating the AMPK/Nrf2 Signaling Pathway
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
por: Shaked, Maayan, et al.
Publicado: (2011)

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia
por: Shen, E., et al.
Publicado: (2009)

Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
por: He, Chaoyong, et al.
Publicado: (2013)

Dexmedetomidine Protects Human Cardiomyocytes Against Ischemia-Reperfusion Injury Through α2-Adrenergic Receptor/AMPK-Dependent Autophagy
por: Xiao, Yingying, et al.
Publicado: (2021)

N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding
por: Cheng, Fengyu, et al.
Publicado: (2022)

Exendin-4 for Parkinson's disease
por: Esparza-Salazar, Felipe de Jesús, et al.
Publicado: (2021)

Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis
por: Li, Tianrong, et al.
Publicado: (2023)

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix
por: Robinson, Emma, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_chv5p5bv93289ee3dakq9qg3bc