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TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

The transient receptor potential ankyrin 1 (TRPA1) channel functions as an irritant sensor and is a therapeutic target for treating pain, itch, and respiratory diseases. As a ligand-gated channel, TRPA1 can be activated by electrophilic compounds such as allyl isothiocyanate (AITC) through covalent...

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Detalles Bibliográficos
Autores principales:	Chernov-Rogan, Tania, Gianti, Eleonora, Liu, Chang, Villemure, Elisia, Cridland, Andrew P., Hu, Xiaoyu, Ballini, Elisa, Lange, Wienke, Deisemann, Heike, Li, Tianbo, Ward, Stuart I., Hackos, David H., Magnuson, Steven, Safina, Brian, Klein, Michael L., Volgraf, Matthew, Carnevale, Vincenzo, Chen, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926016/ https://www.ncbi.nlm.nih.gov/pubmed/31796582 http://dx.doi.org/10.1073/pnas.1913929116

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