Anti-CD20 therapy depletes activated myelin-specific CD8(+) T cells in multiple sclerosis

CD8(+) T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8(+) T cells in MS have relied on in vitro stimulati...

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Detalles Bibliográficos
Autores principales: Sabatino, Joseph J., Wilson, Michael R., Calabresi, Peter A., Hauser, Stephen L., Schneck, Jonathan P., Zamvil, Scott S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926057/
https://www.ncbi.nlm.nih.gov/pubmed/31748274
http://dx.doi.org/10.1073/pnas.1915309116

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