Current role of non-coding RNAs in the clinical setting

Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic mar...

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Autores principales: Vicentini, Caterina, Galuppini, Francesca, Corbo, Vincenzo, Fassan, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926199/
https://www.ncbi.nlm.nih.gov/pubmed/31891017
http://dx.doi.org/10.1016/j.ncrna.2019.09.001
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author Vicentini, Caterina
Galuppini, Francesca
Corbo, Vincenzo
Fassan, Matteo
author_facet Vicentini, Caterina
Galuppini, Francesca
Corbo, Vincenzo
Fassan, Matteo
author_sort Vicentini, Caterina
collection PubMed
description Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic markers for several disorders, predictor for drugs response, and targets for new therapeutic approaches. In this mini-review, we discuss the state of the art of non-coding RNAs in drug development and their involvement in conventional treatments response.
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spelling pubmed-69261992019-12-30 Current role of non-coding RNAs in the clinical setting Vicentini, Caterina Galuppini, Francesca Corbo, Vincenzo Fassan, Matteo Noncoding RNA Res Article Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic markers for several disorders, predictor for drugs response, and targets for new therapeutic approaches. In this mini-review, we discuss the state of the art of non-coding RNAs in drug development and their involvement in conventional treatments response. KeAi Publishing 2019-09-17 /pmc/articles/PMC6926199/ /pubmed/31891017 http://dx.doi.org/10.1016/j.ncrna.2019.09.001 Text en © 2019 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Vicentini, Caterina
Galuppini, Francesca
Corbo, Vincenzo
Fassan, Matteo
Current role of non-coding RNAs in the clinical setting
title Current role of non-coding RNAs in the clinical setting
title_full Current role of non-coding RNAs in the clinical setting
title_fullStr Current role of non-coding RNAs in the clinical setting
title_full_unstemmed Current role of non-coding RNAs in the clinical setting
title_short Current role of non-coding RNAs in the clinical setting
title_sort current role of non-coding rnas in the clinical setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926199/
https://www.ncbi.nlm.nih.gov/pubmed/31891017
http://dx.doi.org/10.1016/j.ncrna.2019.09.001
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