In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subunit of the translation initiation factor eIF3 in the mouse l...

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Detalles Bibliográficos
Autores principales: Smekalova, Elena M., Gerashchenko, Maxim V., O’Connor, Patrick B.F., Whittaker, Charles A., Kauffman, Kevin J., Fefilova, Anna S., Zatsepin, Timofei S., Bogorad, Roman L., Baranov, Pavel V., Langer, Robert, Gladyshev, Vadim N., Anderson, Daniel G., Koteliansky, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926209/
https://www.ncbi.nlm.nih.gov/pubmed/31855834
http://dx.doi.org/10.1016/j.omtn.2019.11.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926209/
https://www.ncbi.nlm.nih.gov/pubmed/31855834
http://dx.doi.org/10.1016/j.omtn.2019.11.009

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