Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

Because many peptide and peptide-mimetic drugs are substrates of peptide transporter 1, it is important to evaluate the peptide transporter 1-mediated intestinal absorption of drug candidates in the early phase of drug development. Although intestinal cell lines treated with inhibitors of peptide tr...

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Detalles Bibliográficos
Autores principales: Kawai, Kanae, Negoro, Ryosuke, Ichikawa, Moe, Yamashita, Tomoki, Deguchi, Sayaka, Harada, Kazuo, Hirata, Kazumasa, Takayama, Kazuo, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926248/
https://www.ncbi.nlm.nih.gov/pubmed/31890740
http://dx.doi.org/10.1016/j.omtm.2019.11.008

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