Cargando…

Inhibition of HDAC6 Attenuates Tumor Growth of Non-Small Cell Lung Cancer

Histone deacetylase 6 (HDAC6) regulates cytoplasmic signaling networks through deacetylation of various cytoplasmic substrates and serves as a key member of the ubiquitin proteasome system (UPS). This study is focused on HDAC6 regulation of the Notch1 receptor that plays a crucial role in tumor grow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deskin, Brian, Yin, Qinyan, Zhuang, Yan, Saito, Shigeki, Shan, Bin, Lasky, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2019
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926313/ https://www.ncbi.nlm.nih.gov/pubmed/31865176 http://dx.doi.org/10.1016/j.tranon.2019.11.001

Ejemplares similares

Requirement of HDAC6 for activation of Notch1 by TGF-β1
por: Deskin, Brian, et al.
Publicado: (2016)

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo
por: Lee, Seung Joon, et al.
Publicado: (2011)

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth
por: Kaliszczak, M, et al.
Publicado: (2013)

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy
por: Abouhish, Hossameldin, et al.
Publicado: (2020)

Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
por: Bertels, Zachariah, et al.
Publicado: (2021)

Arsenic trioxide inhibits EBV reactivation and promotes cell death in EBV-positive lymphoma cells
por: Yin, Qinyan, et al.
Publicado: (2017)

Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo
por: Luo, Fayong, et al.
Publicado: (2014)

Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway
por: Saito, Shigeki, et al.
Publicado: (2017)

HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction
por: Zhu, Chenxi, et al.
Publicado: (2023)

Growth Suppression of Glioma Cells Using HDAC6 Inhibitor, Tubacin
por: Yin, Changjiang, et al.
Publicado: (2018)

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma
por: Garrett, Matthew C., et al.
Publicado: (2023)

Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
por: Yan, Shaoqi, et al.
Publicado: (2020)

HDAC6 Degradation Inhibits the Growth of High-Grade Serous Ovarian Cancer Cells
por: Ali, Ahlam, et al.
Publicado: (2020)

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer
por: Shao, Changjian, et al.
Publicado: (2021)

IL-1β Signaling in the Alveolar Niche: Context Is Everything
por: Deskin, Brian
Publicado: (2023)

Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation
por: Nomura, Yohei, et al.
Publicado: (2021)

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition
por: Kalinski, Ashley L., et al.
Publicado: (2019)

Assessment of viral RNA in idiopathic pulmonary fibrosis using RNA-seq
por: Yin, Qinyan, et al.
Publicado: (2020)

Sodium butyrate attenuates angiotensin II‐induced cardiac hypertrophy by inhibiting COX2/PGE2 pathway via a HDAC5/HDAC6‐dependent mechanism
por: Zhang, Linlin, et al.
Publicado: (2019)

HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1
por: Moses, Niko, et al.
Publicado: (2020)

Down-regulation of HDAC3 inhibits growth of cholangiocarcinoma by inducing apoptosis
por: Zhang, Mingming, et al.
Publicado: (2017)

HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights
por: Passaro, Eugenia, et al.
Publicado: (2021)

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
por: Seo, Jinwon, et al.
Publicado: (2014)

Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
por: Auzmendi-Iriarte, Jaione, et al.
Publicado: (2020)

Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer
por: Yang, Chih-Jen, et al.
Publicado: (2015)

Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome
por: Hou, Qing, et al.
Publicado: (2022)

Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth
por: Takahashi, Akiko, et al.
Publicado: (2015)

NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells
por: Pai, Jih-Tung, et al.
Publicado: (2015)

HDAC6 promotes growth, migration/invasion and self-renewal of rhabdomyosarcoma
por: Pham, Thao Q., et al.
Publicado: (2020)

AKT activation controls cell survival in response to HDAC6 inhibition
por: Kaliszczak, M, et al.
Publicado: (2016)

Inhibition of HDAC6 activity in kidney diseases: a new perspective
por: Ke, Ben, et al.
Publicado: (2018)

The Role of HDAC6 in Cancer
por: Aldana-Masangkay, Grace I., et al.
Publicado: (2011)

HDAC6 and Ovarian Cancer
por: Haakenson, Joshua, et al.
Publicado: (2013)

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells
por: Wang, Lei, et al.
Publicado: (2012)

HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies
por: Yan, Bing, et al.
Publicado: (2017)

Dual inhibition of HDAC and tyrosine kinase signaling pathways with CUDC-907 attenuates TGFβ1 induced lung and tumor fibrosis
por: Zhang, Wentian, et al.
Publicado: (2020)

Palmatine attenuates isoproterenol-induced pathological hypertrophy via selectively inhibiting HDAC2 in rats
por: Yuan, Yonggang, et al.
Publicado: (2017)

Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes
por: Choi, Yun-Jung, et al.
Publicado: (2019)

Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation
por: Lei, Yubin, et al.
Publicado: (2017)

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells
por: Liu, Jiaqi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_u85u30gb1tc7p70lkmmavdi6bu