A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab

A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 che...

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Detalles Bibliográficos
Autores principales: Ito, Keima, Oguri, Tetsuya, Takeda, Norihisa, Fukumitsu, Kensuke, Fukuda, Satoshi, Kanemitsu, Yoshihiro, Tajiri, Tomoko, Ohkubo, Hirotsugu, Takemura, Masaya, Maeno, Ken, Ito, Yutaka, Niimi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926357/
https://www.ncbi.nlm.nih.gov/pubmed/31890556
http://dx.doi.org/10.1016/j.rmcr.2019.100979
Descripción
Sumario:A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 chemotherapy courses were administered over 2 years. Currently, he is being followed with no recurrence at least 10 months after treatment. Thus, the case of a patient with advanced lung cancer who was previously unsuccessfully treated with nivolumab and then demonstrated a long-term clinical response to a re-challenge with nivolumab after cytotoxic chemotherapy and radiation therapy is presented.

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