A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab

A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 che...

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Autores principales: Ito, Keima, Oguri, Tetsuya, Takeda, Norihisa, Fukumitsu, Kensuke, Fukuda, Satoshi, Kanemitsu, Yoshihiro, Tajiri, Tomoko, Ohkubo, Hirotsugu, Takemura, Masaya, Maeno, Ken, Ito, Yutaka, Niimi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926357/
https://www.ncbi.nlm.nih.gov/pubmed/31890556
http://dx.doi.org/10.1016/j.rmcr.2019.100979
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author Ito, Keima
Oguri, Tetsuya
Takeda, Norihisa
Fukumitsu, Kensuke
Fukuda, Satoshi
Kanemitsu, Yoshihiro
Tajiri, Tomoko
Ohkubo, Hirotsugu
Takemura, Masaya
Maeno, Ken
Ito, Yutaka
Niimi, Akio
author_facet Ito, Keima
Oguri, Tetsuya
Takeda, Norihisa
Fukumitsu, Kensuke
Fukuda, Satoshi
Kanemitsu, Yoshihiro
Tajiri, Tomoko
Ohkubo, Hirotsugu
Takemura, Masaya
Maeno, Ken
Ito, Yutaka
Niimi, Akio
author_sort Ito, Keima
collection PubMed
description A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 chemotherapy courses were administered over 2 years. Currently, he is being followed with no recurrence at least 10 months after treatment. Thus, the case of a patient with advanced lung cancer who was previously unsuccessfully treated with nivolumab and then demonstrated a long-term clinical response to a re-challenge with nivolumab after cytotoxic chemotherapy and radiation therapy is presented.
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spelling pubmed-69263572019-12-30 A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab Ito, Keima Oguri, Tetsuya Takeda, Norihisa Fukumitsu, Kensuke Fukuda, Satoshi Kanemitsu, Yoshihiro Tajiri, Tomoko Ohkubo, Hirotsugu Takemura, Masaya Maeno, Ken Ito, Yutaka Niimi, Akio Respir Med Case Rep Case Report A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 chemotherapy courses were administered over 2 years. Currently, he is being followed with no recurrence at least 10 months after treatment. Thus, the case of a patient with advanced lung cancer who was previously unsuccessfully treated with nivolumab and then demonstrated a long-term clinical response to a re-challenge with nivolumab after cytotoxic chemotherapy and radiation therapy is presented. Elsevier 2019-12-10 /pmc/articles/PMC6926357/ /pubmed/31890556 http://dx.doi.org/10.1016/j.rmcr.2019.100979 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ito, Keima
Oguri, Tetsuya
Takeda, Norihisa
Fukumitsu, Kensuke
Fukuda, Satoshi
Kanemitsu, Yoshihiro
Tajiri, Tomoko
Ohkubo, Hirotsugu
Takemura, Masaya
Maeno, Ken
Ito, Yutaka
Niimi, Akio
A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
title A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
title_full A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
title_fullStr A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
title_full_unstemmed A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
title_short A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
title_sort case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926357/
https://www.ncbi.nlm.nih.gov/pubmed/31890556
http://dx.doi.org/10.1016/j.rmcr.2019.100979
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