Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

Quinones can modify biological molecules through both redox-cycling reactions that yield radicals (semiquinone, superoxide and hydroxyl) and via covalent adduction to nucleophiles (e.g. thiols and amines). Kinetic data indicate that Cys residues in GSH and proteins are major targets. In the studies...

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Detalles Bibliográficos
Autores principales: Shu, Nan, Hägglund, Per, Cai, Huan, Hawkins, Clare L., Davies, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926358/
https://www.ncbi.nlm.nih.gov/pubmed/31926625
http://dx.doi.org/10.1016/j.redox.2019.101400

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