Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Infections induce complex host responses linked to antiviral defense, inflammation, and tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may orchestrate systemic metabolic changes during infection. We infected mice with chronic lymphocytic choriomeningitis virus...

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Detalles Bibliográficos
Autores principales: Lercher, Alexander, Bhattacharya, Anannya, Popa, Alexandra M., Caldera, Michael, Schlapansky, Moritz F., Baazim, Hatoon, Agerer, Benedikt, Gürtl, Bettina, Kosack, Lindsay, Májek, Peter, Brunner, Julia S., Vitko, Dijana, Pinter, Theresa, Genger, Jakob-Wendelin, Orlova, Anna, Pikor, Natalia, Reil, Daniela, Ozsvár-Kozma, Maria, Kalinke, Ulrich, Ludewig, Burkhard, Moriggl, Richard, Bennett, Keiryn L., Menche, Jörg, Cheng, Paul N., Schabbauer, Gernot, Trauner, Michael, Klavins, Kristaps, Bergthaler, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926485/
https://www.ncbi.nlm.nih.gov/pubmed/31784108
http://dx.doi.org/10.1016/j.immuni.2019.10.014

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