A Facile Synthesis of Core-Shell SiO(2)@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems

A well-dispersed SiO(2)@Layered hydroxide cupric benzoate (SiO(2)@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO(2)@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and FTIR spectra provide consistent evidence to the formation of SiO(2)@Cu-LBMS nano-microspheres. The release behavior and drug loading capability of SiO(2)@Cu-LBMS microspheres were also investigated by using ibuprofen, aspirin and salicylic acid as model drugs. The results indicated that the drug loading capability of SiO(2)@Cu-LBMS nano-microspheres was much larger than layered hydroxide cupric benzoate, and the releasing time was significantly prolonged than layered hydroxide cupric benzoate and their physical mixture.