Cargando…
Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles va...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926550/ https://www.ncbi.nlm.nih.gov/pubmed/31771262 http://dx.doi.org/10.3390/ijerph16234680 |
_version_ | 1783482115956932608 |
---|---|
author | Chong, Ka Chun Rui, Yan Liu, Yan Zhou, Tianyuan Jia, Katherine Wang, Maggie Haitian Mohammad, Kirran N. He, Hanqing |
author_facet | Chong, Ka Chun Rui, Yan Liu, Yan Zhou, Tianyuan Jia, Katherine Wang, Maggie Haitian Mohammad, Kirran N. He, Hanqing |
author_sort | Chong, Ka Chun |
collection | PubMed |
description | In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women. |
format | Online Article Text |
id | pubmed-6926550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69265502019-12-24 Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys Chong, Ka Chun Rui, Yan Liu, Yan Zhou, Tianyuan Jia, Katherine Wang, Maggie Haitian Mohammad, Kirran N. He, Hanqing Int J Environ Res Public Health Article In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women. MDPI 2019-11-24 2019-12 /pmc/articles/PMC6926550/ /pubmed/31771262 http://dx.doi.org/10.3390/ijerph16234680 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chong, Ka Chun Rui, Yan Liu, Yan Zhou, Tianyuan Jia, Katherine Wang, Maggie Haitian Mohammad, Kirran N. He, Hanqing Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys |
title | Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys |
title_full | Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys |
title_fullStr | Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys |
title_full_unstemmed | Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys |
title_short | Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys |
title_sort | early waning of maternal measles antibodies in infants in zhejiang province, china: a comparison of two cross-sectional serosurveys |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926550/ https://www.ncbi.nlm.nih.gov/pubmed/31771262 http://dx.doi.org/10.3390/ijerph16234680 |
work_keys_str_mv | AT chongkachun earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT ruiyan earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT liuyan earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT zhoutianyuan earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT jiakatherine earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT wangmaggiehaitian earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT mohammadkirrann earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys AT hehanqing earlywaningofmaternalmeaslesantibodiesininfantsinzhejiangprovincechinaacomparisonoftwocrosssectionalserosurveys |