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Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys

In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles va...

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Autores principales: Chong, Ka Chun, Rui, Yan, Liu, Yan, Zhou, Tianyuan, Jia, Katherine, Wang, Maggie Haitian, Mohammad, Kirran N., He, Hanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926550/
https://www.ncbi.nlm.nih.gov/pubmed/31771262
http://dx.doi.org/10.3390/ijerph16234680
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author Chong, Ka Chun
Rui, Yan
Liu, Yan
Zhou, Tianyuan
Jia, Katherine
Wang, Maggie Haitian
Mohammad, Kirran N.
He, Hanqing
author_facet Chong, Ka Chun
Rui, Yan
Liu, Yan
Zhou, Tianyuan
Jia, Katherine
Wang, Maggie Haitian
Mohammad, Kirran N.
He, Hanqing
author_sort Chong, Ka Chun
collection PubMed
description In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women.
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spelling pubmed-69265502019-12-24 Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys Chong, Ka Chun Rui, Yan Liu, Yan Zhou, Tianyuan Jia, Katherine Wang, Maggie Haitian Mohammad, Kirran N. He, Hanqing Int J Environ Res Public Health Article In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women. MDPI 2019-11-24 2019-12 /pmc/articles/PMC6926550/ /pubmed/31771262 http://dx.doi.org/10.3390/ijerph16234680 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chong, Ka Chun
Rui, Yan
Liu, Yan
Zhou, Tianyuan
Jia, Katherine
Wang, Maggie Haitian
Mohammad, Kirran N.
He, Hanqing
Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
title Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
title_full Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
title_fullStr Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
title_full_unstemmed Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
title_short Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
title_sort early waning of maternal measles antibodies in infants in zhejiang province, china: a comparison of two cross-sectional serosurveys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926550/
https://www.ncbi.nlm.nih.gov/pubmed/31771262
http://dx.doi.org/10.3390/ijerph16234680
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