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The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver

The effect of equal-channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, corrosion resistance and cytotoxicity of two magnesium-silver alloys, Mg-2.0%Ag and Mg-4.0%Ag, was studied. Their average grain size was found to be reduced to 3.2 ± 1.4 μm and 2.8 ± 1.3 μm, re...

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Autores principales: Estrin, Yuri, Martynenko, Natalia, Anisimova, Natalia, Temralieva, Diana, Kiselevskiy, Mikhail, Serebryany, Vladimir, Raab, Georgy, Straumal, Boris, Wiese, Björn, Willumeit-Römer, Regine, Dobatkin, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926692/
https://www.ncbi.nlm.nih.gov/pubmed/31766395
http://dx.doi.org/10.3390/ma12233832
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author Estrin, Yuri
Martynenko, Natalia
Anisimova, Natalia
Temralieva, Diana
Kiselevskiy, Mikhail
Serebryany, Vladimir
Raab, Georgy
Straumal, Boris
Wiese, Björn
Willumeit-Römer, Regine
Dobatkin, Sergey
author_facet Estrin, Yuri
Martynenko, Natalia
Anisimova, Natalia
Temralieva, Diana
Kiselevskiy, Mikhail
Serebryany, Vladimir
Raab, Georgy
Straumal, Boris
Wiese, Björn
Willumeit-Römer, Regine
Dobatkin, Sergey
author_sort Estrin, Yuri
collection PubMed
description The effect of equal-channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, corrosion resistance and cytotoxicity of two magnesium-silver alloys, Mg-2.0%Ag and Mg-4.0%Ag, was studied. Their average grain size was found to be reduced to 3.2 ± 1.4 μm and 2.8 ± 1.3 μm, respectively. Despite the substantial grain refinement, a drop in the strength characteristics of the alloys was observed, which can be attributed to the formation of inclined basal texture. On a positive side, an increase in tensile ductility to ~34% for Mg-2.0%Ag and ~27% for Mg-4.0%Ag was observed. This effect can be associated with the activity of basal and prismatic slip induced by ECAP. One of the ECAP regimes tested gave rise to a drop in the corrosion resistance of both alloys. An interesting observation was a cytotoxic effect both alloys had on tumor cells in vitro. This effect was accompanied with the release of lactate dehydrogenase, an increase in oxidative stress, coupled with the induction of NO-ions and an increase in the content of such markers of apoptosis as Annexin V and Caspase 3/7. Differences in the chemical composition and the processing history-dependent microstructure of the alloys did not have any significant effect on the magnitude of their antiproliferative effect.
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spelling pubmed-69266922019-12-24 The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver Estrin, Yuri Martynenko, Natalia Anisimova, Natalia Temralieva, Diana Kiselevskiy, Mikhail Serebryany, Vladimir Raab, Georgy Straumal, Boris Wiese, Björn Willumeit-Römer, Regine Dobatkin, Sergey Materials (Basel) Article The effect of equal-channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, corrosion resistance and cytotoxicity of two magnesium-silver alloys, Mg-2.0%Ag and Mg-4.0%Ag, was studied. Their average grain size was found to be reduced to 3.2 ± 1.4 μm and 2.8 ± 1.3 μm, respectively. Despite the substantial grain refinement, a drop in the strength characteristics of the alloys was observed, which can be attributed to the formation of inclined basal texture. On a positive side, an increase in tensile ductility to ~34% for Mg-2.0%Ag and ~27% for Mg-4.0%Ag was observed. This effect can be associated with the activity of basal and prismatic slip induced by ECAP. One of the ECAP regimes tested gave rise to a drop in the corrosion resistance of both alloys. An interesting observation was a cytotoxic effect both alloys had on tumor cells in vitro. This effect was accompanied with the release of lactate dehydrogenase, an increase in oxidative stress, coupled with the induction of NO-ions and an increase in the content of such markers of apoptosis as Annexin V and Caspase 3/7. Differences in the chemical composition and the processing history-dependent microstructure of the alloys did not have any significant effect on the magnitude of their antiproliferative effect. MDPI 2019-11-21 /pmc/articles/PMC6926692/ /pubmed/31766395 http://dx.doi.org/10.3390/ma12233832 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estrin, Yuri
Martynenko, Natalia
Anisimova, Natalia
Temralieva, Diana
Kiselevskiy, Mikhail
Serebryany, Vladimir
Raab, Georgy
Straumal, Boris
Wiese, Björn
Willumeit-Römer, Regine
Dobatkin, Sergey
The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver
title The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver
title_full The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver
title_fullStr The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver
title_full_unstemmed The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver
title_short The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver
title_sort effect of equal-channel angular pressing on the microstructure, the mechanical and corrosion properties and the anti-tumor activity of magnesium alloyed with silver
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926692/
https://www.ncbi.nlm.nih.gov/pubmed/31766395
http://dx.doi.org/10.3390/ma12233832
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