Cargando…

Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer that is Associated with Poor Outcomes in Endometrial Carcinoma

Background: Pyruvate kinase M2 (PKM2) is a regulator of the processes of glycolysis and oxidative phosphorylation, but the roles that it plays in endometrial cancer remain largely unknown. This study evaluated the PKM2 expression in normal endometrium, endometrial hyperplasia, and endometrial carcin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Yu-Ju, Chou, Yu-Ching, Lin, Yi-Jia, Yu, Mu-Hsien, Ou, Yu-Che, Chu, Po-Wei, Wu, Chia-Chun, Wang, Yu-Chi, Chao, Tai-Kuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926947/ https://www.ncbi.nlm.nih.gov/pubmed/31756939 http://dx.doi.org/10.3390/ijerph16234589

Ejemplares similares

The combination of aldehyde dehydrogenase 1 (ALDH1) and CD44 is associated with poor outcomes in endometrial cancer
por: Huang, Hsin-Hui, et al.
Publicado: (2018)

Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer
por: Chao, Tai-Kuang, et al.
Publicado: (2017)

Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy
por: Martignetti, John A., et al.
Publicado: (2018)

Urokinase-type Plasminogen Activator Resulting from Endometrial Carcinogenesis Enhances Tumor Invasion and Correlates with Poor Outcome of Endometrial Carcinoma Patients
por: Huang, Chia-Yen, et al.
Publicado: (2015)

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway
por: Wang, Yiying, et al.
Publicado: (2016)

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma
por: Kuo, Yu-Hsuan, et al.
Publicado: (2021)

Reliable Identification of Endometrial Precancers Through Combined Pax2, β-Catenin, and Pten Immunohistochemistry
por: Aguilar, Mitzi, et al.
Publicado: (2022)

Methylglyoxal Levels in Human Colorectal Precancer and Cancer: Analysis of Tumor and Peritumor Tissue
por: Chou, Chu-Kuang, et al.
Publicado: (2021)

Quantitative Measurement of Progesterone Receptor Immunohistochemical Expression to Predict Lymph Node Metastasis in Endometrial Cancer
por: Hsiao, Yu-Yang, et al.
Publicado: (2022)

Induction of Apoptosis in Endometrial Cancer (Ishikawa) Cells by Pogostemon cablin Aqueous Extract (PCAE)
por: Tsai, Ching-Chou, et al.
Publicado: (2015)

β-catenin, Pax2, and Pten Panel Identifies Precancers Among Histologically Subdiagnostic Endometrial Lesions
por: Aguilar, Mitzi, et al.
Publicado: (2023)

The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings
por: Chang, Cheng-Chang, et al.
Publicado: (2018)

Loss of ten-eleven translocation 1 (TET1) expression as a diagnostic and prognostic biomarker of endometrial carcinoma
por: Liu, Nien-Tzu, et al.
Publicado: (2021)

Risk factor analysis of coexisting endometrial carcinoma in patients with endometrial hyperplasia: a retrospective observational study of Taiwanese Gynecologic Oncology Group
por: Chen, Yu-Li, et al.
Publicado: (2013)

NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling
por: Lin, Ting-Yu, et al.
Publicado: (2016)

Divergent endometrial inflammatory cytokine expression at peri-implantation period and after the stimulation by copper intrauterine device
por: Chou, Chia-Hung, et al.
Publicado: (2015)

An Efficacious Endometrial Sampler for Screening Endometrial Cancer
por: Han, Lu, et al.
Publicado: (2019)

Expression of CD133 in endometrial cancer cells and its implications
por: Ding, Dah-Ching, et al.
Publicado: (2017)

Effect of cyclin-dependent kinase 7 silencing on cisplatin sensitivity in endometrial carcinoma cells
por: LIU, WEN-XIN, et al.
Publicado: (2015)

Real-World Evaluation of Modern Adjuvant Radiotherapy in Women with Stage IB Endometrial Cancer
por: Chen, Jenny Ling-Yu, et al.
Publicado: (2021)

Diagnosis of oral precancer with optical coherence tomography
por: Lee, Cheng-Kuang, et al.
Publicado: (2012)

Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial Carcinogenesis
por: Chiu, Hsiao-Chen, et al.
Publicado: (2019)

The impact of the COVID-19 pandemic on waiting times for endometrial cancer and precancer surgery: A single institutional experience at the epicenter of the COVID pandemic (517)
por: Seay, Kieran, et al.
Publicado: (2022)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

Muscle radiodensity loss during cancer therapy is predictive for poor survival in advanced endometrial cancer
por: Lee, Jie, et al.
Publicado: (2019)

BMI-1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor
por: Yu, Jing, et al.
Publicado: (2020)

BMI-1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor
por: Yu, Jing, et al.
Publicado: (2022)

Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I
por: Wu, Ching-Yuan, et al.
Publicado: (2023)

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells
por: Yu, Lei, et al.
Publicado: (2019)

Endometrial Cancer Detection Using a Cervical DNA Methylation Assay (MPap) in Women with Abnormal Uterine Bleeding: A Multicenter Hospital-Based Validation Study
por: Wen, Kuo-Chang, et al.
Publicado: (2022)

Effect of Endometrial Injury on Secretion of Endometrial Cytokines and IVF Outcomes in Women with Unexplained Subfertility
por: Liang, Yu, et al.
Publicado: (2015)

Fertility-Sparing Treatment for Endometrial Cancer or Atypical Endometrial Hyperplasia Patients With Obesity
por: Chen, Junyu, et al.
Publicado: (2022)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells
por: Lin, Chi-Shian, et al.
Publicado: (2014)

Haloperidol Instigates Endometrial Carcinogenesis and Cancer Progression by the NF-κB/CSF-1 Signaling Cascade
por: Chiang, Jung-Ying, et al.
Publicado: (2022)

Caesalpinia sappan induces apoptotic cell death in ectopic endometrial 12Z cells through suppressing pyruvate dehydrogenase kinase 1 expression
por: Kim, Bo-Sung, et al.
Publicado: (2021)

Overexpression of claudin-4 may be involved in endometrial tumorigenesis
por: PAN, XIAO-YU, et al.
Publicado: (2013)

Effects of the Overexpression of Progesterone Receptors on a Precancer p53 and Rb-Defective Human Fallopian Tube Epithelial Cell Line
por: Chang, Yu-Hsun, et al.
Publicado: (2023)

Crosstalk between SOX2 and cytokine signaling in endometrial carcinoma
por: Lee, Chang-Jung, et al.
Publicado: (2018)

Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival
por: Kamal, A M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_g4p3c15n89h6jrs9497v65vdn0