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Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock

Electroacupuncture (EA) at ST36 can improve the survival rate in rats after hemorrhagic shock (HS). The current study investigated rats with 60% blood loss. 144 rats were divided into four groups: hemorrhage without fluid resuscitation (HS), EA after hemorrhage without fluid resuscitation (EA), hemo...

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Autores principales: Zhong, Yuxian, Xu, Guochen, Wu, Yushou, Zhang, Huiping, Wang, Haibin, Ma, Liqian, Zhang, Wenhua, Yao, Yongming, Wang, Lu, Hu, Sen, Litscher, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927047/
https://www.ncbi.nlm.nih.gov/pubmed/31885667
http://dx.doi.org/10.1155/2019/8371862
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author Zhong, Yuxian
Xu, Guochen
Wu, Yushou
Zhang, Huiping
Wang, Haibin
Ma, Liqian
Zhang, Wenhua
Yao, Yongming
Wang, Lu
Hu, Sen
Litscher, Gerhard
author_facet Zhong, Yuxian
Xu, Guochen
Wu, Yushou
Zhang, Huiping
Wang, Haibin
Ma, Liqian
Zhang, Wenhua
Yao, Yongming
Wang, Lu
Hu, Sen
Litscher, Gerhard
author_sort Zhong, Yuxian
collection PubMed
description Electroacupuncture (EA) at ST36 can improve the survival rate in rats after hemorrhagic shock (HS). The current study investigated rats with 60% blood loss. 144 rats were divided into four groups: hemorrhage without fluid resuscitation (HS), EA after hemorrhage without fluid resuscitation (EA), hemorrhage with delayed resuscitation (DFR), and EA after hemorrhage with delayed resuscitation (EA + DFR). The survival rate and biological parameters 0, 3, 12, and 24 h after HS were investigated. The 24 h survival rate of EA + DFR was significantly higher than that of DFR. 12 h after hemorrhage, the level of mean arterial blood pressure of EA + DFR was significantly higher than that of DFR, and the levels of renal blood flow, intestinal mucosal blood flow, and hepatic blood flow of EA + DFR were also significantly higher than those of DFR. Three hours after hemorrhage, the levels of lactate, PaCO(2), alanine aminotransferase, and creatinine of groups receiving EA were significantly lower than those of non-EA groups, and the levels of pH, PaO(2), and diamine oxidase of groups receiving EA were significantly higher. EA at ST36 can improve the 24 h survival rate and produce the experimental antishock effects on tissue perfusion and organ protection from fatal HS.
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spelling pubmed-69270472019-12-29 Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock Zhong, Yuxian Xu, Guochen Wu, Yushou Zhang, Huiping Wang, Haibin Ma, Liqian Zhang, Wenhua Yao, Yongming Wang, Lu Hu, Sen Litscher, Gerhard Evid Based Complement Alternat Med Research Article Electroacupuncture (EA) at ST36 can improve the survival rate in rats after hemorrhagic shock (HS). The current study investigated rats with 60% blood loss. 144 rats were divided into four groups: hemorrhage without fluid resuscitation (HS), EA after hemorrhage without fluid resuscitation (EA), hemorrhage with delayed resuscitation (DFR), and EA after hemorrhage with delayed resuscitation (EA + DFR). The survival rate and biological parameters 0, 3, 12, and 24 h after HS were investigated. The 24 h survival rate of EA + DFR was significantly higher than that of DFR. 12 h after hemorrhage, the level of mean arterial blood pressure of EA + DFR was significantly higher than that of DFR, and the levels of renal blood flow, intestinal mucosal blood flow, and hepatic blood flow of EA + DFR were also significantly higher than those of DFR. Three hours after hemorrhage, the levels of lactate, PaCO(2), alanine aminotransferase, and creatinine of groups receiving EA were significantly lower than those of non-EA groups, and the levels of pH, PaO(2), and diamine oxidase of groups receiving EA were significantly higher. EA at ST36 can improve the 24 h survival rate and produce the experimental antishock effects on tissue perfusion and organ protection from fatal HS. Hindawi 2019-12-11 /pmc/articles/PMC6927047/ /pubmed/31885667 http://dx.doi.org/10.1155/2019/8371862 Text en Copyright © 2019 Yuxian Zhong et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhong, Yuxian
Xu, Guochen
Wu, Yushou
Zhang, Huiping
Wang, Haibin
Ma, Liqian
Zhang, Wenhua
Yao, Yongming
Wang, Lu
Hu, Sen
Litscher, Gerhard
Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock
title Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock
title_full Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock
title_fullStr Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock
title_full_unstemmed Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock
title_short Electroacupuncture Improves the Survival Rate and Organ Function in a Rat Model of Hemorrhagic Shock
title_sort electroacupuncture improves the survival rate and organ function in a rat model of hemorrhagic shock
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927047/
https://www.ncbi.nlm.nih.gov/pubmed/31885667
http://dx.doi.org/10.1155/2019/8371862
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