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Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study

BACKGROUND: In this article, we describe our experience in managing one of the worst tragedies of an outbreak of methanol poisoning in the state of Uttarakhand in February 2019. It was reported that more than 100 people of Uttarakhand and neighboring districts of Uttar Pradesh succumbed to death aft...

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Autores principales: Kumar, Manish, Kaeley, Nidhi, Nagasubramanyam, Vempalli, Bhardwaj, Bharat Bhushan, Kumar, Subodh, Kabi, Ankita, Arora, Poonam, Dhar, Mridul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927134/
https://www.ncbi.nlm.nih.gov/pubmed/31879603
http://dx.doi.org/10.4103/IJCIIS.IJCIIS_49_19
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author Kumar, Manish
Kaeley, Nidhi
Nagasubramanyam, Vempalli
Bhardwaj, Bharat Bhushan
Kumar, Subodh
Kabi, Ankita
Arora, Poonam
Dhar, Mridul
author_facet Kumar, Manish
Kaeley, Nidhi
Nagasubramanyam, Vempalli
Bhardwaj, Bharat Bhushan
Kumar, Subodh
Kabi, Ankita
Arora, Poonam
Dhar, Mridul
author_sort Kumar, Manish
collection PubMed
description BACKGROUND: In this article, we describe our experience in managing one of the worst tragedies of an outbreak of methanol poisoning in the state of Uttarakhand in February 2019. It was reported that more than 100 people of Uttarakhand and neighboring districts of Uttar Pradesh succumbed to death after consuming this toxic alcohol laced with methanol. MATERIALS AND METHODS: Demographic, clinical, and biochemical data were collected retrospectively from the hospital record section of the tertiary care hospital in the state of Uttarakhand. RESULTS: Ninety-three patients of methanol poisoning were attended by the emergency medicine department of our hospital. The mean age of the patients was 38.9 ± 10.3 years. Majority of the patients were males (92/93). The most common clinical symptoms were gastrointestinal (56; 60.2%) followed by neurological (21; 22.6%) and respiratory (18; 19.3%). Most of the patients presented within 12–24 h after consumption of methanol. The mean of latent time of presentation was 4.8 ± 2.6 h. The mean values of pH, bicarbonate levels, lactate, and base deficit were 7.13 ± 0.6, 12.3 ± 6.4, 2.6 ± 0.8, and 15.6 ± 3.8 mmol/l, respectively. Acute kidney injury (26; 27.9%), blurring of vision (9; 9.6%), and sepsis (6, 6.4%) were common complications. Seven patients (7.5%) succumbed to death. Intensive alkali therapy was the main modality of treatment. Ethanol therapy was useful in patients resistant to alkali therapy. Sixteen (17.2%) patients with acute methanol poisoning were dialyzed once. CONCLUSION: Patients with acute methanol poisoning have varied presentations. Gastrointestinal symptoms are the most common presentation. Such outbreaks account for the heavy toll of mortality and morbidity in the society. Prompt diagnosis and a protocol based treatment can have a significant impact on the outcome of these patients. Thus, public health warning should be immediately issued with initial presentation of the casualties.
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spelling pubmed-69271342019-12-26 Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study Kumar, Manish Kaeley, Nidhi Nagasubramanyam, Vempalli Bhardwaj, Bharat Bhushan Kumar, Subodh Kabi, Ankita Arora, Poonam Dhar, Mridul Int J Crit Illn Inj Sci Original Article BACKGROUND: In this article, we describe our experience in managing one of the worst tragedies of an outbreak of methanol poisoning in the state of Uttarakhand in February 2019. It was reported that more than 100 people of Uttarakhand and neighboring districts of Uttar Pradesh succumbed to death after consuming this toxic alcohol laced with methanol. MATERIALS AND METHODS: Demographic, clinical, and biochemical data were collected retrospectively from the hospital record section of the tertiary care hospital in the state of Uttarakhand. RESULTS: Ninety-three patients of methanol poisoning were attended by the emergency medicine department of our hospital. The mean age of the patients was 38.9 ± 10.3 years. Majority of the patients were males (92/93). The most common clinical symptoms were gastrointestinal (56; 60.2%) followed by neurological (21; 22.6%) and respiratory (18; 19.3%). Most of the patients presented within 12–24 h after consumption of methanol. The mean of latent time of presentation was 4.8 ± 2.6 h. The mean values of pH, bicarbonate levels, lactate, and base deficit were 7.13 ± 0.6, 12.3 ± 6.4, 2.6 ± 0.8, and 15.6 ± 3.8 mmol/l, respectively. Acute kidney injury (26; 27.9%), blurring of vision (9; 9.6%), and sepsis (6, 6.4%) were common complications. Seven patients (7.5%) succumbed to death. Intensive alkali therapy was the main modality of treatment. Ethanol therapy was useful in patients resistant to alkali therapy. Sixteen (17.2%) patients with acute methanol poisoning were dialyzed once. CONCLUSION: Patients with acute methanol poisoning have varied presentations. Gastrointestinal symptoms are the most common presentation. Such outbreaks account for the heavy toll of mortality and morbidity in the society. Prompt diagnosis and a protocol based treatment can have a significant impact on the outcome of these patients. Thus, public health warning should be immediately issued with initial presentation of the casualties. Wolters Kluwer - Medknow 2019 2019-12-11 /pmc/articles/PMC6927134/ /pubmed/31879603 http://dx.doi.org/10.4103/IJCIIS.IJCIIS_49_19 Text en Copyright: © 2019 International Journal of Critical Illness and Injury Science http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kumar, Manish
Kaeley, Nidhi
Nagasubramanyam, Vempalli
Bhardwaj, Bharat Bhushan
Kumar, Subodh
Kabi, Ankita
Arora, Poonam
Dhar, Mridul
Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study
title Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study
title_full Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study
title_fullStr Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study
title_full_unstemmed Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study
title_short Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study
title_sort single center experience of managing methanol poisoning in the hilly state of uttarakhand: a cross sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927134/
https://www.ncbi.nlm.nih.gov/pubmed/31879603
http://dx.doi.org/10.4103/IJCIIS.IJCIIS_49_19
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