Feature selection and dimension reduction for single-cell RNA-Seq based on a multinomial model

Single-cell RNA-Seq (scRNA-Seq) profiles gene expression of individual cells. Recent scRNA-Seq datasets have incorporated unique molecular identifiers (UMIs). Using negative controls, we show UMI counts follow multinomial sampling with no zero inflation. Current normalization procedures such as log...

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Detalles Bibliográficos
Autores principales: Townes, F. William, Hicks, Stephanie C., Aryee, Martin J., Irizarry, Rafael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927135/
https://www.ncbi.nlm.nih.gov/pubmed/31870412
http://dx.doi.org/10.1186/s13059-019-1861-6

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