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Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions

The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Recent work has shown that these molecules have great potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, anti-cancer agents and anti-inflammatories. A better...

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Detalles Bibliográficos
Autores principales: Raheem, Nigare, Straus, Suzana K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927293/
https://www.ncbi.nlm.nih.gov/pubmed/31921046
http://dx.doi.org/10.3389/fmicb.2019.02866
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author Raheem, Nigare
Straus, Suzana K.
author_facet Raheem, Nigare
Straus, Suzana K.
author_sort Raheem, Nigare
collection PubMed
description The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Recent work has shown that these molecules have great potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, anti-cancer agents and anti-inflammatories. A better understanding of the mechanism of action (MOA) of AMPs is an important part of the discovery of more potent and less toxic AMPs. Many models and techniques have been utilized to describe the MOA. This review will examine how biological assays and biophysical methods can be utilized in the context of the specific antibacterial and antibiofilm functions of AMPs.
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spelling pubmed-69272932020-01-09 Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions Raheem, Nigare Straus, Suzana K. Front Microbiol Microbiology The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Recent work has shown that these molecules have great potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, anti-cancer agents and anti-inflammatories. A better understanding of the mechanism of action (MOA) of AMPs is an important part of the discovery of more potent and less toxic AMPs. Many models and techniques have been utilized to describe the MOA. This review will examine how biological assays and biophysical methods can be utilized in the context of the specific antibacterial and antibiofilm functions of AMPs. Frontiers Media S.A. 2019-12-12 /pmc/articles/PMC6927293/ /pubmed/31921046 http://dx.doi.org/10.3389/fmicb.2019.02866 Text en Copyright © 2019 Raheem and Straus. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Raheem, Nigare
Straus, Suzana K.
Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
title Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
title_full Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
title_fullStr Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
title_full_unstemmed Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
title_short Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
title_sort mechanisms of action for antimicrobial peptides with antibacterial and antibiofilm functions
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927293/
https://www.ncbi.nlm.nih.gov/pubmed/31921046
http://dx.doi.org/10.3389/fmicb.2019.02866
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