Cargando…

NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner

NUMB is an evolutionarily conserved protein that plays an important role in cell adhesion, migration, polarity, and cell fate determination. It has also been shown to play a role in the pathogenesis of certain cancers, although it remains controversial whether NUMB functions as an oncoprotein or tum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Ran, Liu, Xuguang, Voss, Courtney, Qin, Wentao, Dagnino, Lina, Li, Lei, Vigny, Marc, Li, Shawn Shun-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927325/ https://www.ncbi.nlm.nih.gov/pubmed/30726988 http://dx.doi.org/10.1093/jmcb/mjz003

Ejemplares similares

The role of NUMB/NUMB isoforms in cancer stem cells
por: Choi, Hye Yeon, et al.
Publicado: (2021)

ALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors
por: Orentas, Rimas J, et al.
Publicado: (2013)

Targeting high-risk pediatric solid tumors with CAR T cells directed against ALK (anaplastic lymphoma kinase, CD246)
por: Walker, Alec, et al.
Publicado: (2014)

Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling
por: Wang, Zezhou, et al.
Publicado: (2009)

A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
por: Colaluca, Ivan Nicola, et al.
Publicado: (2018)

Primary gastric anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma
por: Tian, Chen, et al.
Publicado: (2016)

Why is That Chin Numb? A Case of Burkitt’s Lymphoma Presenting as Numb Chin Syndrome
por: Neel, Sejal, et al.
Publicado: (2020)

Leukemic manifestation of anaplastic lymphoma kinase-negative-type anaplastic large-cell lymphoma
por: Kim, Jae Wook, et al.
Publicado: (2012)

Anaplastic Lymphoma Kinase in Cutaneous Malignancies
por: Cao, Severine, et al.
Publicado: (2017)

Targeting anaplastic lymphoma kinase in neuroblastoma
por: Umapathy, Ganesh, et al.
Publicado: (2019)

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
por: Guo, Yue, et al.
Publicado: (2022)

A primary retroperitoneal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor thrombosis
por: Li, Jisong, et al.
Publicado: (2018)

Numb controls E-cadherin endocytosis through p120 catenin with aPKC
por: Sato, Kazuhide, et al.
Publicado: (2011)

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
por: Abballe, Luana, et al.
Publicado: (2018)

Anaplastic Lymphoma Kinase Immunocytochemistry in Fine Needle Aspiration Diagnosis of Anaplastic Large-cell Lymphoma
por: Ramteke, Prashant, et al.
Publicado: (2018)

An Exploration into the Origins and Pathogenesis of Anaplastic Large Cell Lymphoma, Anaplastic Lymphoma Kinase (ALK)-Positive
por: Turner, Suzanne D.
Publicado: (2017)

Anaplastic lymphoma kinase–positive anaplastic large cell lymphoma presenting as diffuse pulmonary infiltrates
por: Sato, Shuku, et al.
Publicado: (2020)

Anaplastic lymphoma kinase: signalling in development and disease
por: Palmer, Ruth H., et al.
Publicado: (2009)

Role and targeting of anaplastic lymphoma kinase in cancer
por: Della Corte, Carminia Maria, et al.
Publicado: (2018)

The role of anaplastic lymphoma kinase in pediatric cancers
por: Takita, Junko
Publicado: (2017)

Anaplastic lymphoma kinase inhibitor-associated myositis
por: Uruha, Akinori, et al.
Publicado: (2020)

Anaplastic lymphoma kinase inhibitors and their effect on the kidney
por: Bonilla, Marco, et al.
Publicado: (2022)

Anaplastic lymphoma kinase-special immunity and immunotherapy
por: Guo, Ye, et al.
Publicado: (2022)

Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
por: Knörr, Fabian, et al.
Publicado: (2018)

Anaplastic Lymphoma Kinase- and CD30-Positive Anaplastic Large-Cell Lymphoma of the External Auditory Canal
por: Chen, Shih-Lung, et al.
Publicado: (2021)

Precision therapy with anaplastic lymphoma kinase inhibitor ceritinib in ALK-rearranged anaplastic large cell lymphoma
por: Subbiah, V., et al.
Publicado: (2021)

The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma
por: Hong, Junmou, et al.
Publicado: (2014)

Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma Arising in a Patient with Hypersensitivity to Mosquito Bites
por: Kang, Jin Hee, et al.
Publicado: (2015)

From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL)
por: Werner, Michael T., et al.
Publicado: (2017)

Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma Kinase‒Positive Anaplastic Large Cell Lymphoma
por: Xu, Wendan, et al.
Publicado: (2018)

Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature
por: Liang, Xiaoqin, et al.
Publicado: (2015)

Numb Chin as Signal for Malignancy-Primary Intraosseous Diffuse Large B-Cell Lymphoma of the Mandible
por: Fuessinger, Marc Anton, et al.
Publicado: (2018)

Presence of anaplastic lymphoma kinase in inflammatory breast cancer
por: Robertson, Fredika M, et al.
Publicado: (2013)

Prognostic significance and therapeutic potential of the activation of anaplastic lymphoma kinase/protein kinase B/mammalian target of rapamycin signaling pathway in anaplastic large cell lymphoma
por: Gao, Ju, et al.
Publicado: (2013)

Anaplastic Lymphoma Kinase Confers Resistance to BRAF Kinase Inhibitors in Melanoma
por: Janostiak, Radoslav, et al.
Publicado: (2019)

Current thoughts on cellular functions of numb-associated kinases
por: Huang, Chenxi, et al.
Publicado: (2023)

Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma with extranodal involvement of the thigh muscle: a case report
por: Emori, Makoto, et al.
Publicado: (2014)

Crizotinib in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in the setting of renal insufficiency: a case report
por: Kothari, Shalin, et al.
Publicado: (2016)

Acute leukemic phase of anaplastic lymphoma kinase-anaplastic large cell lymphoma: A case report and review of the literature
por: Zhang, Huai-Feng, et al.
Publicado: (2020)

Lymphomatous Meningitis From Anaplastic Lymphoma Kinase+ Anaplastic Large T-Cell Lymphoma Treated With Lorlatinib: A Case Report
por: Mellacheruvu, Smitha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1p4fc9ngee3ervbp4p7c3ej1bo