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(19)F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode

The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine hydroxylase (BBOX). (1)H and (19)F NMR studies inform on the BBOX mechanism including by providing evidence for cooperativity between monomers in subst...

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Detalles Bibliográficos
Autores principales:	Leśniak, Robert K., Rydzik, Anna M., Kamps, Jos J. A. G., Kahn, Amjad, Claridge, Timothy D. W., Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927413/ https://www.ncbi.nlm.nih.gov/pubmed/31702759 http://dx.doi.org/10.1039/c9cc06466d

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