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Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
Background: Immuno-oncology is a novel target of cancer therapy. Nivolumab is a monoclonal anti-programed death-1 antibody recently used to treat patients with chemotherapy-resistant gastric and gastroesophageal cancer. Although the disease control rate is reported to be very high, few cases demonst...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927466/ https://www.ncbi.nlm.nih.gov/pubmed/31921639 http://dx.doi.org/10.3389/fonc.2019.01375 |
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author | Kashima, Shin Tanabe, Hiroki Tanino, Mishie Kobayashi, Yu Murakami, Yuki Iwama, Takuya Sasaki, Takahiro Kunogi, Takehito Takahashi, Keitaro Ando, Katsuyoshi Ueno, Nobuhiro Moriichi, Kentaro Fukudo, Masahide Tasaki, Yoshikazu Hosokawa, Masao Mizukami, Yusuke Fujiya, Mikihiro Okumura, Toshikatsu |
author_facet | Kashima, Shin Tanabe, Hiroki Tanino, Mishie Kobayashi, Yu Murakami, Yuki Iwama, Takuya Sasaki, Takahiro Kunogi, Takehito Takahashi, Keitaro Ando, Katsuyoshi Ueno, Nobuhiro Moriichi, Kentaro Fukudo, Masahide Tasaki, Yoshikazu Hosokawa, Masao Mizukami, Yusuke Fujiya, Mikihiro Okumura, Toshikatsu |
author_sort | Kashima, Shin |
collection | PubMed |
description | Background: Immuno-oncology is a novel target of cancer therapy. Nivolumab is a monoclonal anti-programed death-1 antibody recently used to treat patients with chemotherapy-resistant gastric and gastroesophageal cancer. Although the disease control rate is reported to be very high, few cases demonstrate a complete response. Case Presentation: A 25-year-old man diagnosed with gastroesophageal cancer was treated with chemotherapy followed by surgical resection. Pathological diagnosis was poorly differentiated adenocarcinoma with distant lymph node metastasis. Residual lymph node metastasis was treated with nivolumab monotherapy, resulting in complete disappearance. No recurrence has been observed for 2 years since discontinuation of nivolumab. This rare case was additionally subjected to pathological and genetic analysis, suggesting that a high tumor mutation burden (10.7 mutations/Mb) might be associated with sensitivity to nivolumab. Summary: We reported a case of advanced gastroesophageal junction cancer with distal lymph node metastasis that was successfully treated with chemotherapy, surgical resection, and nivolumab therapy. An aggressive search for biomarkers implying benefit effects of nivolumab should be performed. |
format | Online Article Text |
id | pubmed-6927466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69274662020-01-09 Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient Kashima, Shin Tanabe, Hiroki Tanino, Mishie Kobayashi, Yu Murakami, Yuki Iwama, Takuya Sasaki, Takahiro Kunogi, Takehito Takahashi, Keitaro Ando, Katsuyoshi Ueno, Nobuhiro Moriichi, Kentaro Fukudo, Masahide Tasaki, Yoshikazu Hosokawa, Masao Mizukami, Yusuke Fujiya, Mikihiro Okumura, Toshikatsu Front Oncol Oncology Background: Immuno-oncology is a novel target of cancer therapy. Nivolumab is a monoclonal anti-programed death-1 antibody recently used to treat patients with chemotherapy-resistant gastric and gastroesophageal cancer. Although the disease control rate is reported to be very high, few cases demonstrate a complete response. Case Presentation: A 25-year-old man diagnosed with gastroesophageal cancer was treated with chemotherapy followed by surgical resection. Pathological diagnosis was poorly differentiated adenocarcinoma with distant lymph node metastasis. Residual lymph node metastasis was treated with nivolumab monotherapy, resulting in complete disappearance. No recurrence has been observed for 2 years since discontinuation of nivolumab. This rare case was additionally subjected to pathological and genetic analysis, suggesting that a high tumor mutation burden (10.7 mutations/Mb) might be associated with sensitivity to nivolumab. Summary: We reported a case of advanced gastroesophageal junction cancer with distal lymph node metastasis that was successfully treated with chemotherapy, surgical resection, and nivolumab therapy. An aggressive search for biomarkers implying benefit effects of nivolumab should be performed. Frontiers Media S.A. 2019-12-16 /pmc/articles/PMC6927466/ /pubmed/31921639 http://dx.doi.org/10.3389/fonc.2019.01375 Text en Copyright © 2019 Kashima, Tanabe, Tanino, Kobayashi, Murakami, Iwama, Sasaki, Kunogi, Takahashi, Ando, Ueno, Moriichi, Fukudo, Tasaki, Hosokawa, Mizukami, Fujiya and Okumura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Kashima, Shin Tanabe, Hiroki Tanino, Mishie Kobayashi, Yu Murakami, Yuki Iwama, Takuya Sasaki, Takahiro Kunogi, Takehito Takahashi, Keitaro Ando, Katsuyoshi Ueno, Nobuhiro Moriichi, Kentaro Fukudo, Masahide Tasaki, Yoshikazu Hosokawa, Masao Mizukami, Yusuke Fujiya, Mikihiro Okumura, Toshikatsu Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient |
title | Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient |
title_full | Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient |
title_fullStr | Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient |
title_full_unstemmed | Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient |
title_short | Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient |
title_sort | lymph node metastasis from gastroesophageal cancer successfully treated by nivolumab: a case report of a young patient |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927466/ https://www.ncbi.nlm.nih.gov/pubmed/31921639 http://dx.doi.org/10.3389/fonc.2019.01375 |
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