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Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient

Background: Immuno-oncology is a novel target of cancer therapy. Nivolumab is a monoclonal anti-programed death-1 antibody recently used to treat patients with chemotherapy-resistant gastric and gastroesophageal cancer. Although the disease control rate is reported to be very high, few cases demonst...

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Autores principales: Kashima, Shin, Tanabe, Hiroki, Tanino, Mishie, Kobayashi, Yu, Murakami, Yuki, Iwama, Takuya, Sasaki, Takahiro, Kunogi, Takehito, Takahashi, Keitaro, Ando, Katsuyoshi, Ueno, Nobuhiro, Moriichi, Kentaro, Fukudo, Masahide, Tasaki, Yoshikazu, Hosokawa, Masao, Mizukami, Yusuke, Fujiya, Mikihiro, Okumura, Toshikatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927466/
https://www.ncbi.nlm.nih.gov/pubmed/31921639
http://dx.doi.org/10.3389/fonc.2019.01375
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author Kashima, Shin
Tanabe, Hiroki
Tanino, Mishie
Kobayashi, Yu
Murakami, Yuki
Iwama, Takuya
Sasaki, Takahiro
Kunogi, Takehito
Takahashi, Keitaro
Ando, Katsuyoshi
Ueno, Nobuhiro
Moriichi, Kentaro
Fukudo, Masahide
Tasaki, Yoshikazu
Hosokawa, Masao
Mizukami, Yusuke
Fujiya, Mikihiro
Okumura, Toshikatsu
author_facet Kashima, Shin
Tanabe, Hiroki
Tanino, Mishie
Kobayashi, Yu
Murakami, Yuki
Iwama, Takuya
Sasaki, Takahiro
Kunogi, Takehito
Takahashi, Keitaro
Ando, Katsuyoshi
Ueno, Nobuhiro
Moriichi, Kentaro
Fukudo, Masahide
Tasaki, Yoshikazu
Hosokawa, Masao
Mizukami, Yusuke
Fujiya, Mikihiro
Okumura, Toshikatsu
author_sort Kashima, Shin
collection PubMed
description Background: Immuno-oncology is a novel target of cancer therapy. Nivolumab is a monoclonal anti-programed death-1 antibody recently used to treat patients with chemotherapy-resistant gastric and gastroesophageal cancer. Although the disease control rate is reported to be very high, few cases demonstrate a complete response. Case Presentation: A 25-year-old man diagnosed with gastroesophageal cancer was treated with chemotherapy followed by surgical resection. Pathological diagnosis was poorly differentiated adenocarcinoma with distant lymph node metastasis. Residual lymph node metastasis was treated with nivolumab monotherapy, resulting in complete disappearance. No recurrence has been observed for 2 years since discontinuation of nivolumab. This rare case was additionally subjected to pathological and genetic analysis, suggesting that a high tumor mutation burden (10.7 mutations/Mb) might be associated with sensitivity to nivolumab. Summary: We reported a case of advanced gastroesophageal junction cancer with distal lymph node metastasis that was successfully treated with chemotherapy, surgical resection, and nivolumab therapy. An aggressive search for biomarkers implying benefit effects of nivolumab should be performed.
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spelling pubmed-69274662020-01-09 Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient Kashima, Shin Tanabe, Hiroki Tanino, Mishie Kobayashi, Yu Murakami, Yuki Iwama, Takuya Sasaki, Takahiro Kunogi, Takehito Takahashi, Keitaro Ando, Katsuyoshi Ueno, Nobuhiro Moriichi, Kentaro Fukudo, Masahide Tasaki, Yoshikazu Hosokawa, Masao Mizukami, Yusuke Fujiya, Mikihiro Okumura, Toshikatsu Front Oncol Oncology Background: Immuno-oncology is a novel target of cancer therapy. Nivolumab is a monoclonal anti-programed death-1 antibody recently used to treat patients with chemotherapy-resistant gastric and gastroesophageal cancer. Although the disease control rate is reported to be very high, few cases demonstrate a complete response. Case Presentation: A 25-year-old man diagnosed with gastroesophageal cancer was treated with chemotherapy followed by surgical resection. Pathological diagnosis was poorly differentiated adenocarcinoma with distant lymph node metastasis. Residual lymph node metastasis was treated with nivolumab monotherapy, resulting in complete disappearance. No recurrence has been observed for 2 years since discontinuation of nivolumab. This rare case was additionally subjected to pathological and genetic analysis, suggesting that a high tumor mutation burden (10.7 mutations/Mb) might be associated with sensitivity to nivolumab. Summary: We reported a case of advanced gastroesophageal junction cancer with distal lymph node metastasis that was successfully treated with chemotherapy, surgical resection, and nivolumab therapy. An aggressive search for biomarkers implying benefit effects of nivolumab should be performed. Frontiers Media S.A. 2019-12-16 /pmc/articles/PMC6927466/ /pubmed/31921639 http://dx.doi.org/10.3389/fonc.2019.01375 Text en Copyright © 2019 Kashima, Tanabe, Tanino, Kobayashi, Murakami, Iwama, Sasaki, Kunogi, Takahashi, Ando, Ueno, Moriichi, Fukudo, Tasaki, Hosokawa, Mizukami, Fujiya and Okumura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kashima, Shin
Tanabe, Hiroki
Tanino, Mishie
Kobayashi, Yu
Murakami, Yuki
Iwama, Takuya
Sasaki, Takahiro
Kunogi, Takehito
Takahashi, Keitaro
Ando, Katsuyoshi
Ueno, Nobuhiro
Moriichi, Kentaro
Fukudo, Masahide
Tasaki, Yoshikazu
Hosokawa, Masao
Mizukami, Yusuke
Fujiya, Mikihiro
Okumura, Toshikatsu
Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
title Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
title_full Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
title_fullStr Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
title_full_unstemmed Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
title_short Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient
title_sort lymph node metastasis from gastroesophageal cancer successfully treated by nivolumab: a case report of a young patient
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927466/
https://www.ncbi.nlm.nih.gov/pubmed/31921639
http://dx.doi.org/10.3389/fonc.2019.01375
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