T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity

The cytokine interleukin-1β (IL-1β) is a key mediator of anti-microbial immunity as well as autoimmune inflammation. Production of IL-1β requires transcription by innate immune receptor signaling and maturational cleavage by inflammasomes. Whether this mechanism applies to IL-1β production seen in T...

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Detalles Bibliográficos
Autores principales: Jain, Aakanksha, Irizarry-Caro, Ricardo A., McDaniel, Margaret M., Chawla, Amanpreet Singh, Carroll, Kaitlin R., Overcast, Garrett R., Philip, Naomi H., Oberst, Andrew, Chervonsky, Alexander V., Katz, Jonathan D., Pasare, Chandrashekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927526/
https://www.ncbi.nlm.nih.gov/pubmed/31848486
http://dx.doi.org/10.1038/s41590-019-0559-y

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