Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we show that EC-sphingosine-1-phosphate receptor 1 (S1PR1) amplifies VEGFR2-mediated angiogenic signaling to enhance tumor growth. We...

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Detalles Bibliográficos
Autores principales: Ragunathrao, Vijay Avin Balaji, Anwar, Mumtaz, Akhter, Md Zahid, Chavez, Alejandra, Mao, De Yu, Natarajan, Viswanathan, Lakshmikanthan, Sribalaji, Chrzanowska-Wodnicka, Magdalena, Dudek, Arkadiusz Z., Claesson-Welsh, Lena, Kitajewski, Jan K., Wary, Kishore K., Malik, Asrar B., Mehta, Dolly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927555/
https://www.ncbi.nlm.nih.gov/pubmed/31825830
http://dx.doi.org/10.1016/j.celrep.2019.11.036

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