Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy

Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activ...

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Autores principales: Shi, Zhi-Zhou, Fan, Ze-Wen, Chen, Yun-Xia, Xie, Xiu-Feng, Jiang, Wen, Wang, Wen-Jun, Qiu, Yun-Tan, Bai, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927606/
https://www.ncbi.nlm.nih.gov/pubmed/31908494
http://dx.doi.org/10.2147/OTT.S232852
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author Shi, Zhi-Zhou
Fan, Ze-Wen
Chen, Yun-Xia
Xie, Xiu-Feng
Jiang, Wen
Wang, Wen-Jun
Qiu, Yun-Tan
Bai, Jie
author_facet Shi, Zhi-Zhou
Fan, Ze-Wen
Chen, Yun-Xia
Xie, Xiu-Feng
Jiang, Wen
Wang, Wen-Jun
Qiu, Yun-Tan
Bai, Jie
author_sort Shi, Zhi-Zhou
collection PubMed
description Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.
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spelling pubmed-69276062020-01-06 Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy Shi, Zhi-Zhou Fan, Ze-Wen Chen, Yun-Xia Xie, Xiu-Feng Jiang, Wen Wang, Wen-Jun Qiu, Yun-Tan Bai, Jie Onco Targets Ther Review Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data. Dove 2019-12-19 /pmc/articles/PMC6927606/ /pubmed/31908494 http://dx.doi.org/10.2147/OTT.S232852 Text en © 2019 Shi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Shi, Zhi-Zhou
Fan, Ze-Wen
Chen, Yun-Xia
Xie, Xiu-Feng
Jiang, Wen
Wang, Wen-Jun
Qiu, Yun-Tan
Bai, Jie
Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
title Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
title_full Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
title_fullStr Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
title_full_unstemmed Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
title_short Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
title_sort ferroptosis in carcinoma: regulatory mechanisms and new method for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927606/
https://www.ncbi.nlm.nih.gov/pubmed/31908494
http://dx.doi.org/10.2147/OTT.S232852
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