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Self-association of human beta-galactocerebrosidase: Dependence on pH, salt, and surfactant
Krabbe disease, also known as globoid cell leukodystrophy, is a rare genetic neurodegenerative disease caused by a deficiency of the galactocerebrosidase enzyme. To understand the association status of human beta-galactocerebrosidase (hGALC) in solution, we employed analytical ultracentrifugation (A...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927645/ https://www.ncbi.nlm.nih.gov/pubmed/31869371 http://dx.doi.org/10.1371/journal.pone.0226618 |