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Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, but the mechanism linking different mutations to disease-relevant phenotypes...

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Detalles Bibliográficos
Autores principales:	Battaglia, Rachel A, Beltran, Adriana S, Delic, Samed, Dumitru, Raluca, Robinson, Jasmine A, Kabiraj, Parijat, Herring, Laura E, Madden, Victoria J, Ravinder, Namritha, Willems, Erik, Newman, Rhonda A, Quinlan, Roy A, Goldman, James E, Perng, Ming-Der, Inagaki, Masaki, Snider, Natasha T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927689/ https://www.ncbi.nlm.nih.gov/pubmed/31682229 http://dx.doi.org/10.7554/eLife.47789

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