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Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity

Up-regulation of the persistent sodium current (I(NaP)) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here identified calpain as the driver of the up- and down-regulation of I(NaP) and KCC2, respectively, in neonatal rat lumbar moto...

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Detalles Bibliográficos
Autores principales:	Plantier, Vanessa, Sanchez-Brualla, Irene, Dingu, Nejada, Brocard, Cécile, Liabeuf, Sylvie, Gackière, Florian, Brocard, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927741/ https://www.ncbi.nlm.nih.gov/pubmed/31815668 http://dx.doi.org/10.7554/eLife.51404

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