Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important goal of vaccine design. To define bNAb targets, we characterized 28 antibodies belonging to expanded and hypermutated clonal families identified...

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Detalles Bibliográficos
Autores principales: Durham, Natasha D, Agrawal, Aditi, Waltari, Eric, Croote, Derek, Zanini, Fabio, Fouch, Mallorie, Davidson, Edgar, Smith, Olivia, Carabajal, Esteban, Pak, John E, Doranz, Benjamin J, Robinson, Makeda, Sanz, Ana M, Albornoz, Ludwig L, Rosso, Fernando, Einav, Shirit, Quake, Stephen R, McCutcheon, Krista M, Goo, Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927745/
https://www.ncbi.nlm.nih.gov/pubmed/31820734
http://dx.doi.org/10.7554/eLife.52384

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