Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bispecific IgG(4) antibody, which has anomalously high viscosit...

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Detalles Bibliográficos
Autores principales: Tilegenova, Cholpon, Izadi, Saeed, Yin, Jianping, Huang, Christine S., Wu, Jiansheng, Ellerman, Diego, Hymowitz, Sarah G., Walters, Benjamin, Salisbury, Cleo, Carter, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927759/
https://www.ncbi.nlm.nih.gov/pubmed/31779513
http://dx.doi.org/10.1080/19420862.2019.1692764

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