Cargando…

Harnessing MerTK agonism for targeted therapeutics

Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically sil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kedage, Vivekananda, Ellerman, Diego, Chen, Yongmei, Liang, Wei-Ching, Borneo, Joven, Wu, Yan, Yan, Minhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927767/ https://www.ncbi.nlm.nih.gov/pubmed/31852344 http://dx.doi.org/10.1080/19420862.2019.1685832

Ejemplares similares

MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines
por: Kim, Jung Eun, et al.
Publicado: (2017)

The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
por: Wang, Li, et al.
Publicado: (2022)

MerTK is a novel therapeutic target in gastric cancer
por: Yi, Jun Ho, et al.
Publicado: (2015)

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
por: Knubel, Kristina H., et al.
Publicado: (2014)

MerTK, a risk factor for NASH fibrosis
por: Wang, Xiaobo, et al.
Publicado: (2020)

MerTK is required for apoptotic cell–induced T cell tolerance
por: Wallet, Mark A., et al.
Publicado: (2008)

N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth
por: Liu, Yongzhang, et al.
Publicado: (2022)

High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells
por: Puddu, Alessandra, et al.
Publicado: (2022)

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
por: Triantafyllou, Evangelos, et al.
Publicado: (2018)

MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS
por: Healy, Luke M., et al.
Publicado: (2017)

Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency
por: Lew, Deborah S., et al.
Publicado: (2020)

Targeted Phagocytosis Induction for Cancer Immunotherapy via Bispecific MerTK-Engaging Antibodies
por: Carrara, Stefania C., et al.
Publicado: (2022)

Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia
por: Brandao, L N, et al.
Publicado: (2013)

Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment
por: Wang, Kai-Hung, et al.
Publicado: (2020)

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
por: Myers, Kayla V., et al.
Publicado: (2019)

Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
por: Myers Chen, Kayla V., et al.
Publicado: (2023)

Gsk3β regulates the resolution of liver ischemia/reperfusion injury via MerTK
por: Zhang, Hanwen, et al.
Publicado: (2023)

CLEC5a-directed bispecific antibody for effective cellular phagocytosis
por: Kedage, Vivekananda, et al.
Publicado: (2022)

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis
por: Novitskiy, Sergey V., et al.
Publicado: (2019)

Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
por: Pastore, Mirella, et al.
Publicado: (2022)

Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers
por: Grabiec, Aleksander M, et al.
Publicado: (2018)

Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats
por: Pelé, Thomas, et al.
Publicado: (2021)

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition
por: Xue, Gongda, et al.
Publicado: (2017)

Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model
por: Zou, Zaofeng, et al.
Publicado: (2020)

Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development
por: Park, Tae Hyun, et al.
Publicado: (2020)

MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction
por: Shirakawa, Kohsuke, et al.
Publicado: (2020)

Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC
por: Giroud, Paul, et al.
Publicado: (2020)

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients
por: Mohd Idrus, Fatin Najiah, et al.
Publicado: (2021)

Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK
por: Mao, Yingyu, et al.
Publicado: (2021)

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
por: Jhang, Kyoung A., et al.
Publicado: (2018)

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression
por: Lin, Jinti, et al.
Publicado: (2022)

Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway
por: Yang, Jing, et al.
Publicado: (2018)

KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
por: Du, Wenwen, et al.
Publicado: (2020)

GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells
por: Kim, Joo Won, et al.
Publicado: (2022)

Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development
por: Pipitone, Rosaria Maria, et al.
Publicado: (2022)

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
por: Zizzo, Gaetano, et al.
Publicado: (2015)

Inclusion of MERS‐spike protein ELISA in algorithm to determine serologic evidence of MERS‐CoV infection
por: Trivedi, Suvang, et al.
Publicado: (2017)

Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers
por: Singh, Swarnima, et al.
Publicado: (2020)

Molecular mechanism of agonism and inverse agonism in ghrelin receptor
por: Qin, Jiao, et al.
Publicado: (2022)

Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells
por: Selvaraj, Nagarathinam, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ngdfbpjk37q0f55g1aokgbl320