Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

The development of mechanism-based, multiscale pharmacokinetic–pharmacodynamic (PK-PD) models for chimeric antigen receptor (CAR)-T cells is needed to enable investigation of in vitro and in vivo correlation of CAR-T cell responses and to facilitate preclinical-to-clinical translation. Toward this g...

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Detalles Bibliográficos
Autores principales: Singh, Aman P., Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J., Zong, Alice, Wang, Weirong, Heald, Donald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927769/
https://www.ncbi.nlm.nih.gov/pubmed/31852337
http://dx.doi.org/10.1080/19420862.2019.1688616

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