Cargando…

Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry

Bispecific monoclonal antibodies (BsAbs) are engineered proteins with multiple functionalities and properties. The “bi-specificity” of these complex biopharmaceuticals is a key characteristic for the development of novel and more effective therapeutic strategies. The high structural complexity of Bs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gstöttner, Christoph, Reusch, Dietmar, Haberger, Markus, Dragan, Irina, Van Veelen, Peter, Kilgour, David P. A., Tsybin, Yury O., van der Burgt, Yuri E. M., Wuhrer, Manfred, Nicolardi, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927770/ https://www.ncbi.nlm.nih.gov/pubmed/31630606 http://dx.doi.org/10.1080/19420862.2019.1682403

Ejemplares similares

Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry
por: van der Burgt, Yuri E.M., et al.
Publicado: (2018)

Glycan and Protein Analysis of Glycoengineered Bacterial E. coli Vaccines by MALDI-in-Source Decay FT-ICR Mass Spectrometry
por: Nicolardi, Simone, et al.
Publicado: (2022)

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS
por: Kotsias, Maximilianos, et al.
Publicado: (2021)

Improved N- and C-Terminal Sequencing of Proteins by Combining Positive and Negative Ion MALDI In-Source Decay Mass Spectrometry
por: Nicolardi, Simone, et al.
Publicado: (2020)

Analysis of Synthetic Monodisperse Polysaccharides by Wide Mass Range Ultrahigh-Resolution MALDI Mass Spectrometry
por: Nicolardi, Simone, et al.
Publicado: (2021)

Evaluation of Sibling and Twin Fragment Ions Improves the Structural Characterization of Proteins by Top-Down MALDI In-Source Decay Mass Spectrometry
por: Nicolardi, Simone, et al.
Publicado: (2020)

Structural Characterization of Biofunctionalized Gold Nanoparticles by Ultrahigh-Resolution Mass Spectrometry
por: Nicolardi, Simone, et al.
Publicado: (2017)

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches
por: Kooijman, Pieter C., et al.
Publicado: (2019)

Affinity purification of erythropoietin from cell culture supernatant combined with MALDI-TOF-MS analysis of erythropoietin N-glycosylation
por: Falck, David, et al.
Publicado: (2017)

Analysis of Volatile and Nonvolatile Constituents in Gin by Direct-Infusion Ultrahigh-Resolution ESI/APPI FT-ICR Mass Spectrometry
por: Dou, Yanning, et al.
Publicado: (2023)

Quadrupole-detection FT-ICR mass spectrometry
por: Schweikhard, L, et al.
Publicado: (1989)

Streamlined Multimodal DESI and MALDI Mass Spectrometry Imaging on a Singular Dual-Source FT-ICR Mass Spectrometer
por: Zemaitis, Kevin J., et al.
Publicado: (2021)

Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems
por: Forcisi, Sara, et al.
Publicado: (2022)

Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome
por: Kunzke, Thomas, et al.
Publicado: (2017)

Affinity Capillary Electrophoresis–Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody–Receptor Interactions
por: Gstöttner, Christoph, et al.
Publicado: (2021)

Ultra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS
por: Bowman, Andrew P., et al.
Publicado: (2020)

Automated Plasma Glycomics with Linkage-Specific Sialic Acid Esterification and Ultrahigh Resolution MS
por: Vreeker, Gerda C. M., et al.
Publicado: (2018)

Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS
por: Hasegawa, Mina, et al.
Publicado: (2010)

Parametric-mode excitation/dipole-mode detection FT-ICR
por: Schweikhard, L, et al.
Publicado: (1990)

FT-ICR-MS reveals the molecular imprints of the brewing process
por: Pieczonka, Stefan A., et al.
Publicado: (2023)

A new detection scheme for FT-ICR spectrometry in Penning traps
por: Schweikhard, L, et al.
Publicado: (1989)

Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry
por: Lippold, Steffen, et al.
Publicado: (2019)

FT-ICR Mass Spectrometry Imaging at Extreme Mass Resolving Power Using a Dynamically Harmonized ICR Cell with 1ω or 2ω Detection
por: Tiquet, Mathieu, et al.
Publicado: (2022)

Usage of FT-ICR-MS Metabolomics for Characterizing the Chemical Signatures of Barrel-Aged Whisky
por: Roullier-Gall, Chloé, et al.
Publicado: (2018)

MetaboDirect: an analytical pipeline for the processing of FT-ICR MS-based metabolomic data
por: Ayala-Ortiz, Christian, et al.
Publicado: (2023)

In-House Standard Method for Molecular Characterization of Dissolved Organic Matter by FT-ICR Mass Spectrometry
por: He, Chen, et al.
Publicado: (2020)

Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
por: Cramer, Dario A. T., et al.
Publicado: (2023)

Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry
por: Demus, Daniel, et al.
Publicado: (2021)

Multi-Segment Direct Inject nano-ESI-LTQ-FT-ICR-MS/MS For Protein Identification
por: Chen, Jing, et al.
Publicado: (2011)

Simultaneous monitoring of the radial modes of the ion motion and their manipulation in Penning traps by FT-ICR mass spectrometry
por: Breitenfeldt, M, et al.
Publicado: (2007)

Profiling Murchison Soluble Organic Matter for New Organic Compounds with APPI- and ESI-FT-ICR MS
por: Hertzog, Jasmine, et al.
Publicado: (2019)

Longitudinal monitoring of immunoglobulin A glycosylation during pregnancy by simultaneous MALDI-FTICR-MS analysis of N- and O-glycopeptides
por: Bondt, Albert, et al.
Publicado: (2016)

Affinity capillary electrophoresis – mass spectrometry permits direct binding assessment of IgG and FcγRIIa in a glycoform-resolved manner
por: Gstöttner, Christoph, et al.
Publicado: (2022)

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics
por: Tyshchuk, Oksana, et al.
Publicado: (2019)

Discovery of Ovarian Cancer Biomarkers in Serum Using NanoLC Electrospray Ionization TOF and FT-ICR Mass Spectrometry
por: Bergen, H. Robert, et al.
Publicado: (2004)

Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry
por: Zeng, Wenjuan, et al.
Publicado: (2019)

Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry
por: Tao, Yeqing, et al.
Publicado: (2017)

Characterization of resin extracted from guayule (Parthenium argentatum): A dataset including GC–MS and FT-ICR MS
por: Dehghanizadeh, Mostafa, et al.
Publicado: (2020)

Data processing for fennel protein characterization by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS)
por: Melfi, Maria Teresa, et al.
Publicado: (2021)

Characterization of the global metabolic profile of liquiritin in rat plasma, urine, bile and feces based on UHPLC-FT-ICR MS
por: Ma, Li, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8nh8ut25kqoiksioihp7hqvudp