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Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds

INTRODUCTION: Survivin is a nodal protein involved in several cellular pathways. It is a member of the IAP family and an integral component of the chromosomal passenger complex, where it binds to borealin and INCENP through its dimerization interface. By targeting survivin with a small molecule at i...

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Detalles Bibliográficos
Autores principales:	Ibrahim, Tamer M, Ernst, Christoph, Lange, Andreas, Hennig, Susanne, Boeckler, Frank M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927794/ https://www.ncbi.nlm.nih.gov/pubmed/31908412 http://dx.doi.org/10.2147/DDDT.S224561

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