A MYC/GCN2/eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

Tumours depend on altered rates of protein synthesis for growth and survival, suggesting that mechanisms controlling mRNA translation may be exploitable for therapy. Here, we show that loss of APC, which occurs almost universally in colorectal tumours, strongly enhances the dependence on the transla...

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Detalles Bibliográficos
Autores principales: Schmidt, Stefanie, Gay, David, Uthe, Friedrich Wilhelm, Denk, Sarah, Paauwe, Madelon, Matthes, Niels, Diefenbacher, Markus Elmar, Bryson, Sheila, Warrander, Fiona Clare, Erhard, Florian, Ade, Carsten Patrick, Baluapuri, Apoorva, Walz, Susanne, Jackstadt, Rene, Ford, Catriona, Vlachogiannis, Georgios, Valeri, Nicola, Otto, Christoph, Schülein-Völk, Christina, Maurus, Katja, Schmitz, Werner, Knight, John Raymond Philip, Wolf, Elmar, Strathdee, Douglas, Schulze, Almut, Germer, Christoph-Thomas, Rosenwald, Andreas, Sansom, Owen James, Eilers, Martin, Wiegering, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927814/
https://www.ncbi.nlm.nih.gov/pubmed/31685988
http://dx.doi.org/10.1038/s41556-019-0408-0

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