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Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles

The distinct features of ATPSs (aqueous two-phase systems) have made it possible to promote the extraction efficiency of biomolecules. The purpose of this study is to discover an appropriate nanoparticle to design an economical optimal separation process, and to understand the underlying molecular m...

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Autores principales: Nouri, Mitra, Shahriari, Shahla, Pazuki, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927956/
https://www.ncbi.nlm.nih.gov/pubmed/31873132
http://dx.doi.org/10.1038/s41598-019-56120-8
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author Nouri, Mitra
Shahriari, Shahla
Pazuki, Gholamreza
author_facet Nouri, Mitra
Shahriari, Shahla
Pazuki, Gholamreza
author_sort Nouri, Mitra
collection PubMed
description The distinct features of ATPSs (aqueous two-phase systems) have made it possible to promote the extraction efficiency of biomolecules. The purpose of this study is to discover an appropriate nanoparticle to design an economical optimal separation process, and to understand the underlying molecular mechanism which allows the partitioning of vanillin as a phenolic compound using nanoparticle-based ATPSs. To this aim, the capabilities of several different nanoparticles were investigated as additives for boosting the partition coefficient of vanillin in two different ATPSs made up of polyethylene glycol and sodium sulfate/polyethylene glycol and dextran. Also, in an attempt to explain the salting-out effect, the NRTL (Non-random Two Liquid) thermodynamic model was applied. The impact of very small amounts of modified carbon nanotubes on the enhancement of the partition coefficient of vanillin in the ATPS consisting of the biocompatible polymer(s) and salt was quite remarkable. The results showed that the partition coefficient of vanillin grew by almost 127 percent compared to the system without nanoparticle. The molecular mechanism underlying the increase in the partition coefficient was interpreted by taking advantage of structural analyses.
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spelling pubmed-69279562019-12-27 Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles Nouri, Mitra Shahriari, Shahla Pazuki, Gholamreza Sci Rep Article The distinct features of ATPSs (aqueous two-phase systems) have made it possible to promote the extraction efficiency of biomolecules. The purpose of this study is to discover an appropriate nanoparticle to design an economical optimal separation process, and to understand the underlying molecular mechanism which allows the partitioning of vanillin as a phenolic compound using nanoparticle-based ATPSs. To this aim, the capabilities of several different nanoparticles were investigated as additives for boosting the partition coefficient of vanillin in two different ATPSs made up of polyethylene glycol and sodium sulfate/polyethylene glycol and dextran. Also, in an attempt to explain the salting-out effect, the NRTL (Non-random Two Liquid) thermodynamic model was applied. The impact of very small amounts of modified carbon nanotubes on the enhancement of the partition coefficient of vanillin in the ATPS consisting of the biocompatible polymer(s) and salt was quite remarkable. The results showed that the partition coefficient of vanillin grew by almost 127 percent compared to the system without nanoparticle. The molecular mechanism underlying the increase in the partition coefficient was interpreted by taking advantage of structural analyses. Nature Publishing Group UK 2019-12-23 /pmc/articles/PMC6927956/ /pubmed/31873132 http://dx.doi.org/10.1038/s41598-019-56120-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nouri, Mitra
Shahriari, Shahla
Pazuki, Gholamreza
Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
title Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
title_full Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
title_fullStr Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
title_full_unstemmed Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
title_short Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
title_sort increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927956/
https://www.ncbi.nlm.nih.gov/pubmed/31873132
http://dx.doi.org/10.1038/s41598-019-56120-8
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