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Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles
The distinct features of ATPSs (aqueous two-phase systems) have made it possible to promote the extraction efficiency of biomolecules. The purpose of this study is to discover an appropriate nanoparticle to design an economical optimal separation process, and to understand the underlying molecular m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927956/ https://www.ncbi.nlm.nih.gov/pubmed/31873132 http://dx.doi.org/10.1038/s41598-019-56120-8 |
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author | Nouri, Mitra Shahriari, Shahla Pazuki, Gholamreza |
author_facet | Nouri, Mitra Shahriari, Shahla Pazuki, Gholamreza |
author_sort | Nouri, Mitra |
collection | PubMed |
description | The distinct features of ATPSs (aqueous two-phase systems) have made it possible to promote the extraction efficiency of biomolecules. The purpose of this study is to discover an appropriate nanoparticle to design an economical optimal separation process, and to understand the underlying molecular mechanism which allows the partitioning of vanillin as a phenolic compound using nanoparticle-based ATPSs. To this aim, the capabilities of several different nanoparticles were investigated as additives for boosting the partition coefficient of vanillin in two different ATPSs made up of polyethylene glycol and sodium sulfate/polyethylene glycol and dextran. Also, in an attempt to explain the salting-out effect, the NRTL (Non-random Two Liquid) thermodynamic model was applied. The impact of very small amounts of modified carbon nanotubes on the enhancement of the partition coefficient of vanillin in the ATPS consisting of the biocompatible polymer(s) and salt was quite remarkable. The results showed that the partition coefficient of vanillin grew by almost 127 percent compared to the system without nanoparticle. The molecular mechanism underlying the increase in the partition coefficient was interpreted by taking advantage of structural analyses. |
format | Online Article Text |
id | pubmed-6927956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69279562019-12-27 Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles Nouri, Mitra Shahriari, Shahla Pazuki, Gholamreza Sci Rep Article The distinct features of ATPSs (aqueous two-phase systems) have made it possible to promote the extraction efficiency of biomolecules. The purpose of this study is to discover an appropriate nanoparticle to design an economical optimal separation process, and to understand the underlying molecular mechanism which allows the partitioning of vanillin as a phenolic compound using nanoparticle-based ATPSs. To this aim, the capabilities of several different nanoparticles were investigated as additives for boosting the partition coefficient of vanillin in two different ATPSs made up of polyethylene glycol and sodium sulfate/polyethylene glycol and dextran. Also, in an attempt to explain the salting-out effect, the NRTL (Non-random Two Liquid) thermodynamic model was applied. The impact of very small amounts of modified carbon nanotubes on the enhancement of the partition coefficient of vanillin in the ATPS consisting of the biocompatible polymer(s) and salt was quite remarkable. The results showed that the partition coefficient of vanillin grew by almost 127 percent compared to the system without nanoparticle. The molecular mechanism underlying the increase in the partition coefficient was interpreted by taking advantage of structural analyses. Nature Publishing Group UK 2019-12-23 /pmc/articles/PMC6927956/ /pubmed/31873132 http://dx.doi.org/10.1038/s41598-019-56120-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nouri, Mitra Shahriari, Shahla Pazuki, Gholamreza Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
title | Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
title_full | Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
title_fullStr | Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
title_full_unstemmed | Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
title_short | Increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
title_sort | increase of vanillin partitioning using aqueous two phase system with promising nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927956/ https://www.ncbi.nlm.nih.gov/pubmed/31873132 http://dx.doi.org/10.1038/s41598-019-56120-8 |
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