Cargando…

Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity

Background: Insulin plays a pivotal role in the regulation of both carbohydrate and lipid intermediate turnover and metabolism. In the transition from a fasted to fed state, insulin action inhibits lipolysis in adipocytes, and acylcarnitine synthesis in the muscles and heart. The aim of this study w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Makarova, Elina, Makrecka-Kuka, Marina, Vilks, Karlis, Volska, Kristine, Sevostjanovs, Eduards, Grinberga, Solveiga, Zarkova-Malkova, Olga, Dambrova, Maija, Liepinsh, Edgars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927987/ https://www.ncbi.nlm.nih.gov/pubmed/31920980 http://dx.doi.org/10.3389/fendo.2019.00870

Ejemplares similares

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues
por: Makrecka-Kuka, Marina, et al.
Publicado: (2017)

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice
por: Kuka, Janis, et al.
Publicado: (2020)

Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism
por: Vilks, Karlis, et al.
Publicado: (2021)

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
por: Kuka, Janis, et al.
Publicado: (2021)

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults
por: Liepinsh, Edgars, et al.
Publicado: (2020)

Excretion of the Polymyxin Derivative NAB739 in Murine Urine
por: Vaara, Martti, et al.
Publicado: (2020)

The brain acylcarnitine profile depends on nutritional state
por: Svalbe, Baiba, et al.
Publicado: (2015)

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury
por: Vilskersts, Reinis, et al.
Publicado: (2020)

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia
por: Makrecka‐Kuka, Marina, et al.
Publicado: (2020)

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity
por: Zelencova-Gopejenko, Diana, et al.
Publicado: (2023)

Data on cardiac and vascular functionality in ex vivo and in vivo models following acute administration of trimethylamine N-oxide
por: Videja, Melita, et al.
Publicado: (2023)

Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19
por: Vilskersts, Reinis, et al.
Publicado: (2021)

Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling
por: Papatheodorou, Ioanna, et al.
Publicado: (2022)

Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers
por: Videja, Melita, et al.
Publicado: (2022)

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure
por: Videja, Melita, et al.
Publicado: (2021)

Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry
por: Svalbe, Baiba, et al.
Publicado: (2019)

Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels
por: Liepinsh, Edgars, et al.
Publicado: (2023)

Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury
por: Kupats, Einars, et al.
Publicado: (2020)

The Association of Circulating L-Carnitine, γ-Butyrobetaine and Trimethylamine N-Oxide Levels with Gastric Cancer
por: Stonāns, Ilmārs, et al.
Publicado: (2023)

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production
por: Makrecka-Kuka, Marina, et al.
Publicado: (2020)

Efficacy of Proanthocyanidins from Pelargonium sidoides Root Extract in Reducing P. gingivalis Viability While Preserving Oral Commensal S. salivarius
por: Savickiene, Nijole, et al.
Publicado: (2018)

The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants
por: Krizhanovska, Valerija, et al.
Publicado: (2021)

Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from Pelargonium sidoides DC Root Extract
por: Jekabsone, Aiste, et al.
Publicado: (2019)

Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia
por: Veisa, Vija, et al.
Publicado: (2021)

Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
por: Stelfa, Gundega, et al.
Publicado: (2021)

Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice
por: Svalbe, Baiba, et al.
Publicado: (2022)

Opportunities of Amlodipine as a Potential Candidate in the Evaluation of Drug Compliance during Antihypertensive Therapy
por: Kustovs, Dmitrijs, et al.
Publicado: (2023)

Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions
por: Sile, Inga, et al.
Publicado: (2022)

NMR Characterization of Long-Chain Fatty Acylcarnitine Binding to the Mitochondrial Carnitine/Acylcarnitine Carrier
por: Zhang, Ningning, et al.
Publicado: (2022)

Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
por: Sou, Tomás, et al.
Publicado: (2020)

High-Resolution Respirometry for Simultaneous Measurement of Oxygen and Hydrogen Peroxide Fluxes in Permeabilized Cells, Tissue Homogenate and Isolated Mitochondria
por: Makrecka-Kuka, Marina, et al.
Publicado: (2015)

Development of local strontium ranelate delivery systems and long term in vitro drug release studies in osteogenic medium
por: Loca, Dagnija, et al.
Publicado: (2018)

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
por: Becker, Katja, et al.
Publicado: (2021)

Editorial: Lipotoxicity, mitotoxicity, and drug targets
por: Krako Jakovljevic, Nina, et al.
Publicado: (2023)

The significance of acylcarnitine ratio indices in diagnosing carnitine-acylcarnitine translocase deficiency
por: Shi, Congcong, et al.
Publicado: (2023)

Acylcarnitine ratio indices in diagnosing carnitine-acylcarnitine translocase deficiency in newborns
por: Tan, Yifei, et al.
Publicado: (2023)

Long-Chain Acylcarnitines Regulate the hERG Channel
por: Ferro, Fabio, et al.
Publicado: (2012)

Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance
por: Makrecka-Kuka, Marina, et al.
Publicado: (2022)

Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
por: Saiki, Shinji, et al.
Publicado: (2017)

Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines
por: van der Hooft, Justin J. J., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4jc84o43o11ubr1979stpd6jfa