Conformation Transition of Intracellular Part of Glucagon Receptor in Complex With Agonist Glucagon by Conventional and Accelerated Molecular Dynamics Simulations

The inactive conformations of glucagon receptor (GCGR) are widely reported by crystal structures that support the precision structure for drug discovery of type 2 diabetes. The previous study shows that the intracellular part is open in the glucagon-bound GCGR (glu-GCGR) and closed in the apo-GCGR b...

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Detalles Bibliográficos
Autores principales: Bai, Qifeng, Tan, Shuoyan, Pérez-Sánchez, Horacio, Feng, Haixia, Feng, Liya, Liu, HuanXiang, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928006/
https://www.ncbi.nlm.nih.gov/pubmed/31921774
http://dx.doi.org/10.3389/fchem.2019.00851

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