Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013

To understand the genetic diversity and patterns of circulation of rhinoviruses (RV) and enteroviruses (EV) in Singapore, we retrospectively screened 2950 nasal swab samples collected from adults presenting to primary care services with signs of febrile illness in Singapore during 2007‐2013 using se...

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Autores principales: Linster, Martin, Donato, Celeste, Mah, Marcus G., Grau, Miguel L., Low, Jenny G., Ooi, Eng Eong, Su, Yvonne C.F., Smith, Gavin J.D., Vijaykrishna, Dhanasekaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Short Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928033/
https://www.ncbi.nlm.nih.gov/pubmed/31568667
http://dx.doi.org/10.1111/irv.12662
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author Linster, Martin
Donato, Celeste
Mah, Marcus G.
Grau, Miguel L.
Low, Jenny G.
Ooi, Eng Eong
Su, Yvonne C.F.
Smith, Gavin J.D.
Vijaykrishna, Dhanasekaran
author_facet Linster, Martin
Donato, Celeste
Mah, Marcus G.
Grau, Miguel L.
Low, Jenny G.
Ooi, Eng Eong
Su, Yvonne C.F.
Smith, Gavin J.D.
Vijaykrishna, Dhanasekaran
author_sort Linster, Martin
collection PubMed
description To understand the genetic diversity and patterns of circulation of rhinoviruses (RV) and enteroviruses (EV) in Singapore, we retrospectively screened 2950 nasal swab samples collected from adults presenting to primary care services with signs of febrile illness in Singapore during 2007‐2013 using sequencing and phylogenetic methods. Through sequencing and phylogenetic analysis, our results show the year‐round circulation of the three rhinovirus species, A, B, and C. A diverse set of RV/EV serotypes were detected in Singapore with a predominance of RV‐A in all years, whereas serotypes EV‐C A21 and EV‐D68 were only sporadically detected. This study highlights the previously unrecognized diversity and burden in the adult population in Singapore.
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spelling pubmed-69280332020-01-01 Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013 Linster, Martin Donato, Celeste Mah, Marcus G. Grau, Miguel L. Low, Jenny G. Ooi, Eng Eong Su, Yvonne C.F. Smith, Gavin J.D. Vijaykrishna, Dhanasekaran Influenza Other Respir Viruses Short Articles To understand the genetic diversity and patterns of circulation of rhinoviruses (RV) and enteroviruses (EV) in Singapore, we retrospectively screened 2950 nasal swab samples collected from adults presenting to primary care services with signs of febrile illness in Singapore during 2007‐2013 using sequencing and phylogenetic methods. Through sequencing and phylogenetic analysis, our results show the year‐round circulation of the three rhinovirus species, A, B, and C. A diverse set of RV/EV serotypes were detected in Singapore with a predominance of RV‐A in all years, whereas serotypes EV‐C A21 and EV‐D68 were only sporadically detected. This study highlights the previously unrecognized diversity and burden in the adult population in Singapore. John Wiley and Sons Inc. 2019-09-30 2020-01 /pmc/articles/PMC6928033/ /pubmed/31568667 http://dx.doi.org/10.1111/irv.12662 Text en © 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Articles
Linster, Martin
Donato, Celeste
Mah, Marcus G.
Grau, Miguel L.
Low, Jenny G.
Ooi, Eng Eong
Su, Yvonne C.F.
Smith, Gavin J.D.
Vijaykrishna, Dhanasekaran
Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013
title Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013
title_full Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013
title_fullStr Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013
title_full_unstemmed Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013
title_short Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐2013
title_sort genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, singapore, 2007‐2013
topic Short Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928033/
https://www.ncbi.nlm.nih.gov/pubmed/31568667
http://dx.doi.org/10.1111/irv.12662
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