SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

Growth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate appropriate foliation and lobule formation. Indee...

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Detalles Bibliográficos
Autores principales: Petroni, Marialaura, Sahùn Roncero, Maria, Ramponi, Valentina, Fabretti, Francesca, Nicolis Di Robilant, Vittoria, Moretti, Marta, Alfano, Vincenzo, Corsi, Alessandro, De Panfilis, Simone, Giubettini, Maria, Di Giulio, Stefano, Capalbo, Carlo, Belardinilli, Francesca, Coppa, Anna, Sardina, Francesca, Colicchia, Valeria, Pedretti, Flaminia, Infante, Paola, Cardinali, Beatrice, Tessitore, Alessandra, Canettieri, Gianluca, De Smaele, Enrico, Giannini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928071/
https://www.ncbi.nlm.nih.gov/pubmed/31873117
http://dx.doi.org/10.1038/s41598-019-56057-y

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