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Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis
Autoimmune haemolytic anaemia (AIHA) is a kind of autoimmune diseases characterized by autoantibodies which produced and secreted by abnormal activated B lymphocytes directed against red blood cells (RBC). Study reveals that about 50% AIHA mainly occurs secondary to lymphoproliferative disorders (LP...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928151/ https://www.ncbi.nlm.nih.gov/pubmed/31873137 http://dx.doi.org/10.1038/s41598-019-56162-y |
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author | Xing, Limin Zhao, Manjun Wang, Yi Feng, Yingying Qu, Yingying Duan, Ningning Wang, Yihao Wang, Huaquan Liu, Chunyan Qu, Wen Wu, Yuhong Guan, Jing Wang, Guojin Song, Jia Li, Lijuan Wang, Xiaoming Fu, Rong Shao, Zonghong |
author_facet | Xing, Limin Zhao, Manjun Wang, Yi Feng, Yingying Qu, Yingying Duan, Ningning Wang, Yihao Wang, Huaquan Liu, Chunyan Qu, Wen Wu, Yuhong Guan, Jing Wang, Guojin Song, Jia Li, Lijuan Wang, Xiaoming Fu, Rong Shao, Zonghong |
author_sort | Xing, Limin |
collection | PubMed |
description | Autoimmune haemolytic anaemia (AIHA) is a kind of autoimmune diseases characterized by autoantibodies which produced and secreted by abnormal activated B lymphocytes directed against red blood cells (RBC). Study reveals that about 50% AIHA mainly occurs secondary to lymphoproliferative disorders (LPD) and autoimmune diseases. In this study, we aim to explore the characteristics of patients with AIHA secondary to LPD. Fifteen patients with AIHA secondary to LPD (secondary group) and 60 with primary AIHA (primary group) were retrospectively included. Patients in the secondary group [(59.40 ± 4.74) y] were older than those in the primary group [(47.53 ± 2.30) y] (p = 0.024). Reticulocyte counts were lower for the secondary group [(134.55 ± 20.67) × 10(9)/L] than for the primary group [(193.88 ± 27.32) × 10(9)/L] (p = 0.09). Haptoglobin was higher in the secondary (0.75 ± 0.19) g/L than in the primary group (0.34 ± 0.05) g/L (p = 0.004). The ratio of CD3(+)CD4(+)/CD3(+)CD8(+) was higher in the secondary (1.81 ± 0.41) than in the primary (1.05 ± 0.12) group (p = 0.025). Duration of remission was shorter in the secondary [(23.52 ± 5.20) months] than in the primary [(40.87 ± 3.92) months] group (p = 0.013). Relapse rate was higher for the secondary (33.3%) than for the primary (8.3%) group (p = 0.003). Mortality rate was higher in the secondary (33.3%) than in the primary (8.3%) group (p = 0.003). Progression-free survival was shorter in the secondary than in the primary group (p = 0.021). In conclusion, patients with AIHA secondary to LPD showed higher age at diagnosis, shorter remission time, and higher recurrence and mortality rates than did those with primary AIHA. |
format | Online Article Text |
id | pubmed-6928151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69281512019-12-27 Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis Xing, Limin Zhao, Manjun Wang, Yi Feng, Yingying Qu, Yingying Duan, Ningning Wang, Yihao Wang, Huaquan Liu, Chunyan Qu, Wen Wu, Yuhong Guan, Jing Wang, Guojin Song, Jia Li, Lijuan Wang, Xiaoming Fu, Rong Shao, Zonghong Sci Rep Article Autoimmune haemolytic anaemia (AIHA) is a kind of autoimmune diseases characterized by autoantibodies which produced and secreted by abnormal activated B lymphocytes directed against red blood cells (RBC). Study reveals that about 50% AIHA mainly occurs secondary to lymphoproliferative disorders (LPD) and autoimmune diseases. In this study, we aim to explore the characteristics of patients with AIHA secondary to LPD. Fifteen patients with AIHA secondary to LPD (secondary group) and 60 with primary AIHA (primary group) were retrospectively included. Patients in the secondary group [(59.40 ± 4.74) y] were older than those in the primary group [(47.53 ± 2.30) y] (p = 0.024). Reticulocyte counts were lower for the secondary group [(134.55 ± 20.67) × 10(9)/L] than for the primary group [(193.88 ± 27.32) × 10(9)/L] (p = 0.09). Haptoglobin was higher in the secondary (0.75 ± 0.19) g/L than in the primary group (0.34 ± 0.05) g/L (p = 0.004). The ratio of CD3(+)CD4(+)/CD3(+)CD8(+) was higher in the secondary (1.81 ± 0.41) than in the primary (1.05 ± 0.12) group (p = 0.025). Duration of remission was shorter in the secondary [(23.52 ± 5.20) months] than in the primary [(40.87 ± 3.92) months] group (p = 0.013). Relapse rate was higher for the secondary (33.3%) than for the primary (8.3%) group (p = 0.003). Mortality rate was higher in the secondary (33.3%) than in the primary (8.3%) group (p = 0.003). Progression-free survival was shorter in the secondary than in the primary group (p = 0.021). In conclusion, patients with AIHA secondary to LPD showed higher age at diagnosis, shorter remission time, and higher recurrence and mortality rates than did those with primary AIHA. Nature Publishing Group UK 2019-12-23 /pmc/articles/PMC6928151/ /pubmed/31873137 http://dx.doi.org/10.1038/s41598-019-56162-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xing, Limin Zhao, Manjun Wang, Yi Feng, Yingying Qu, Yingying Duan, Ningning Wang, Yihao Wang, Huaquan Liu, Chunyan Qu, Wen Wu, Yuhong Guan, Jing Wang, Guojin Song, Jia Li, Lijuan Wang, Xiaoming Fu, Rong Shao, Zonghong Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis |
title | Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis |
title_full | Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis |
title_fullStr | Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis |
title_full_unstemmed | Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis |
title_short | Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis |
title_sort | characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: a single-centre retrospective analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928151/ https://www.ncbi.nlm.nih.gov/pubmed/31873137 http://dx.doi.org/10.1038/s41598-019-56162-y |
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