An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on t...

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Autores principales: Yang, Yang, Zhao, Weihua, Tan, Wenwen, Lai, Zongqiang, Fang, Dong, Jiang, Lei, Zuo, Chuantian, Yang, Nuo, Lai, Yongrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928176/
https://www.ncbi.nlm.nih.gov/pubmed/31872318
http://dx.doi.org/10.1186/s11671-019-3208-3
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author Yang, Yang
Zhao, Weihua
Tan, Wenwen
Lai, Zongqiang
Fang, Dong
Jiang, Lei
Zuo, Chuantian
Yang, Nuo
Lai, Yongrong
author_facet Yang, Yang
Zhao, Weihua
Tan, Wenwen
Lai, Zongqiang
Fang, Dong
Jiang, Lei
Zuo, Chuantian
Yang, Nuo
Lai, Yongrong
author_sort Yang, Yang
collection PubMed
description How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. In this work, Sgc8-MSN/Dox showed sustained Dox release, and they targeted and efficiently killed CCRF-CEM human acute T lymphocyte leukemia cells, suggesting potential as a cancer therapy.
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spelling pubmed-69281762020-01-08 An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles Yang, Yang Zhao, Weihua Tan, Wenwen Lai, Zongqiang Fang, Dong Jiang, Lei Zuo, Chuantian Yang, Nuo Lai, Yongrong Nanoscale Res Lett Nano Express How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. In this work, Sgc8-MSN/Dox showed sustained Dox release, and they targeted and efficiently killed CCRF-CEM human acute T lymphocyte leukemia cells, suggesting potential as a cancer therapy. Springer US 2019-12-23 /pmc/articles/PMC6928176/ /pubmed/31872318 http://dx.doi.org/10.1186/s11671-019-3208-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Yang, Yang
Zhao, Weihua
Tan, Wenwen
Lai, Zongqiang
Fang, Dong
Jiang, Lei
Zuo, Chuantian
Yang, Nuo
Lai, Yongrong
An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
title An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
title_full An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
title_fullStr An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
title_full_unstemmed An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
title_short An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
title_sort efficient cell-targeting drug delivery system based on aptamer-modified mesoporous silica nanoparticles
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928176/
https://www.ncbi.nlm.nih.gov/pubmed/31872318
http://dx.doi.org/10.1186/s11671-019-3208-3
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