Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

Serine hydroxymethyltransferases (SHMTs) reversibly transform serine into glycine in a reaction accompanied with conversion of tetrahydrofolate (THF) into 5,10-methylene-THF (5,10-meTHF). In vivo, 5,10-meTHF is the main carrier of one-carbon (1C) units, which are utilized for nucleotide biosynthesis...

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Detalles Bibliográficos
Autores principales: Ruszkowski, Milosz, Sekula, Bartosz, Ruszkowska, Agnieszka, Contestabile, Roberto, Nogues, Isabel, Angelaccio, Sebastiana, Szczepaniak, Andrzej, Dauter, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928210/
https://www.ncbi.nlm.nih.gov/pubmed/31873125
http://dx.doi.org/10.1038/s41598-019-56043-4

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