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[(13)C(6),D(8)]2-deoxyglucose phosphorylation by hexokinase shows selectivity for the β-anomer

A non-radioactive 2-deoxyglucose (2DG) analog has been developed here for hyperpolarized magnetic resonance investigations. The analog, [(13)C(6),D(8)]2DG, showed 13% polarization in solution (27,000-fold signal enhancement at the C(1) site), following a dissolution-DNP hyperpolarization process. Th...

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Detalles Bibliográficos
Autores principales:	Sapir, Gal, Harris, Talia, Uppala, Sivaranjan, Nardi-Schreiber, Atara, Sosna, Jacob, Gomori, J. Moshe, Katz-Brull, Rachel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928223/ https://www.ncbi.nlm.nih.gov/pubmed/31873121 http://dx.doi.org/10.1038/s41598-019-56063-0

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