Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirma...

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Detalles Bibliográficos
Autores principales: Kavitha, Naidu, Karunya, Thennarasu Padmini, Kanchana, Shankar, Mohan, Kumar, Sivaramakrishnan, Ramachandiran, Uthra, Selvaraj, Kapilan, Kalimuthu, Yuvaraj, Dinakarkumar, Arumugam, Muthuvel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928261/
https://www.ncbi.nlm.nih.gov/pubmed/31890939
http://dx.doi.org/10.1016/j.heliyon.2019.e02916
Descripción
Sumario:Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era.

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