Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirma...

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Autores principales: Kavitha, Naidu, Karunya, Thennarasu Padmini, Kanchana, Shankar, Mohan, Kumar, Sivaramakrishnan, Ramachandiran, Uthra, Selvaraj, Kapilan, Kalimuthu, Yuvaraj, Dinakarkumar, Arumugam, Muthuvel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928261/
https://www.ncbi.nlm.nih.gov/pubmed/31890939
http://dx.doi.org/10.1016/j.heliyon.2019.e02916
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author Kavitha, Naidu
Karunya, Thennarasu Padmini
Kanchana, Shankar
Mohan, Kumar
Sivaramakrishnan, Ramachandiran
Uthra, Selvaraj
Kapilan, Kalimuthu
Yuvaraj, Dinakarkumar
Arumugam, Muthuvel
author_facet Kavitha, Naidu
Karunya, Thennarasu Padmini
Kanchana, Shankar
Mohan, Kumar
Sivaramakrishnan, Ramachandiran
Uthra, Selvaraj
Kapilan, Kalimuthu
Yuvaraj, Dinakarkumar
Arumugam, Muthuvel
author_sort Kavitha, Naidu
collection PubMed
description Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era.
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spelling pubmed-69282612019-12-30 Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications Kavitha, Naidu Karunya, Thennarasu Padmini Kanchana, Shankar Mohan, Kumar Sivaramakrishnan, Ramachandiran Uthra, Selvaraj Kapilan, Kalimuthu Yuvaraj, Dinakarkumar Arumugam, Muthuvel Heliyon Article Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era. Elsevier 2019-12-19 /pmc/articles/PMC6928261/ /pubmed/31890939 http://dx.doi.org/10.1016/j.heliyon.2019.e02916 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kavitha, Naidu
Karunya, Thennarasu Padmini
Kanchana, Shankar
Mohan, Kumar
Sivaramakrishnan, Ramachandiran
Uthra, Selvaraj
Kapilan, Kalimuthu
Yuvaraj, Dinakarkumar
Arumugam, Muthuvel
Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
title Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
title_full Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
title_fullStr Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
title_full_unstemmed Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
title_short Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
title_sort formulation of alginate based hydrogel from brown seaweed, turbinaria conoides for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928261/
https://www.ncbi.nlm.nih.gov/pubmed/31890939
http://dx.doi.org/10.1016/j.heliyon.2019.e02916
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