Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function

The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood. Mature AgRP((83-132)) has distinct residues for melanocortin receptor binding and heparan sulfate interactions. Here, we show that A...

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Detalles Bibliográficos
Autores principales: Chen, Jihuan, Chen, Valerie, Kawamura, Tomoya, Hoang, Ivy, Yang, Yang, Wong, Ashley Tess, McBride, Ryan, Repunte-Canonigo, Vez, Millhauser, Glenn L., Sanna, Pietro Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928319/
https://www.ncbi.nlm.nih.gov/pubmed/31863782
http://dx.doi.org/10.1016/j.isci.2019.10.061

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