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Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report

BACKGROUND: The use of eculizumab during pregnancy has generally been discouraged. Published data on related studies provides conflicting information and establishing a benefit-risk relationship proves to be a complicated task. Miscarriage rates, concomitant medications, and the stages of pregnancy...

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Autores principales: Rodríguez-Ferreras, Adrián, Velasco-Roces, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928406/
https://www.ncbi.nlm.nih.gov/pubmed/31897393
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author Rodríguez-Ferreras, Adrián
Velasco-Roces, Lucia
author_facet Rodríguez-Ferreras, Adrián
Velasco-Roces, Lucia
author_sort Rodríguez-Ferreras, Adrián
collection PubMed
description BACKGROUND: The use of eculizumab during pregnancy has generally been discouraged. Published data on related studies provides conflicting information and establishing a benefit-risk relationship proves to be a complicated task. Miscarriage rates, concomitant medications, and the stages of pregnancy when eculizumab treatment was initiated varied among the patients included in the case series. The aim of this report is to discuss eculizumab use during pregnancy. CASE PRESENTATION: A case of a woman diagnosed with Paroxysmal Nocturnal Hemoglobinuria (PNH) and treated with eculizumab, who expressed desire for pregnancy is presented. Six months after her eculizumab treatment, the patient experienced spontaneous abortion in her first trimester. The direct relation between eculizumab and the miscarriage is not clear. Other factors may have influenced this case, thus demonstrating the difficulty of managing pregnancy in women with PNH. CONCLUSION: Controversy on eculizumab risk during pregnancy encourages further review on its use, highlighting the importance to assess each case individually.
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spelling pubmed-69284062020-01-02 Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report Rodríguez-Ferreras, Adrián Velasco-Roces, Lucia J Reprod Infertil Case Report BACKGROUND: The use of eculizumab during pregnancy has generally been discouraged. Published data on related studies provides conflicting information and establishing a benefit-risk relationship proves to be a complicated task. Miscarriage rates, concomitant medications, and the stages of pregnancy when eculizumab treatment was initiated varied among the patients included in the case series. The aim of this report is to discuss eculizumab use during pregnancy. CASE PRESENTATION: A case of a woman diagnosed with Paroxysmal Nocturnal Hemoglobinuria (PNH) and treated with eculizumab, who expressed desire for pregnancy is presented. Six months after her eculizumab treatment, the patient experienced spontaneous abortion in her first trimester. The direct relation between eculizumab and the miscarriage is not clear. Other factors may have influenced this case, thus demonstrating the difficulty of managing pregnancy in women with PNH. CONCLUSION: Controversy on eculizumab risk during pregnancy encourages further review on its use, highlighting the importance to assess each case individually. Avicenna Research Institute 2019 /pmc/articles/PMC6928406/ /pubmed/31897393 Text en Copyright© 2019, Avicenna Research Institute. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rodríguez-Ferreras, Adrián
Velasco-Roces, Lucia
Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report
title Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report
title_full Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report
title_fullStr Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report
title_full_unstemmed Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report
title_short Eculizumab-Related Abortion in a Woman with Paroxysmal Nocturnal Hemoglobinuria: A Case Report
title_sort eculizumab-related abortion in a woman with paroxysmal nocturnal hemoglobinuria: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928406/
https://www.ncbi.nlm.nih.gov/pubmed/31897393
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